{"publication_id":"fa3d00ab-72a0-4cb6-aaa0-48b50e0f9875","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Potential biomarkers for early periodontal inflammation: investigating CD5 + B cells, salivary cytokines and oral microbiome","doi":"10.1038/s41598-026-37044-6","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis","doi":"10.1038/s41522-024-00476-x","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Oral Microbiome Signatures in Periodontitis and Edentulism—A Population‐Based Study","doi":"10.1111/jre.70046","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"The Oral Microbiome across Oral Sites in Cats with Chronic Gingivostomatitis, Periodontal Disease, and Tooth Resorption Compared with Healthy Cats","doi":"10.3390/ani13223544","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Non‐Surgical Periodontal Therapy Modulates Oral Microbiome in Primary Immunodeficient Children","doi":"10.1111/jcpe.14201","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Multi‐Omics Signatures of Periodontitis and Periodontal Therapy on the Oral and Gut Microbiome","doi":"10.1111/jre.70055","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Involvement of propionate, citrulline, homoserine, and succinate in oral microbiome metabolite-driven periodontal disease progression","doi":"10.1038/s41598-025-91105-w","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Oral Microbiome in Relation to Periodontitis Severity and Systemic Inflammation","doi":"10.3390/ijms22115876","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"The Oral Microbiome in Queensland Free-Ranging Koalas ( Phascolarctos cinereus ) and Its Association with Age and Periodontal Disease","doi":"10.3390/ani15131834","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Dysbiosis of oral microbiome persists after dental treatment-induced remission of periodontal disease and dental caries","doi":"10.1128/msystems.00683-23","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Oral microbiome brain axis and cognitive performance in older adults","doi":"10.1038/s44400-025-00004-4","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Association between Periodontal Disease and Alzheimer's Disease Risk Factors: A Longitudinal Oral Microbiome Study","doi":"10.1002/alz70856_103436","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Neutrophils at the Crossroads of Oral Microbiome Dysbiosis and Periodontal Disease","doi":"10.3390/microorganisms13112573","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"}]}