{"publication_id":"f9eee40c-93ea-461f-b51b-e766983b9da2","content_hash":"sha256:f4729786802f9461f0de65bfb4ac49e691e480e543b7ec01ebc0ffa537dffebe","nodes":[{"id":"f9eee40c-93ea-461f-b51b-e766983b9da2","type":"publication","title":"Exercise: evidence map — 18 findings across 18 sources"},{"id":"claim_1","type":"claim","text":"This evidence map surveys 18 independent exercise sources drawn from the Tier-2 corpus and classified as direct findings. They vary across population, comparator, and/or endpoint and are catalogued by source in the Findings Map rather than pooled into one estimate — cross-population aggregation is not claimed. Each row records its own population, comparator, endpoint, and effect, so the spread of the literature and any tensions between findings remain explicit."},{"id":"claim_2","type":"claim","text":"| men and women | — | elicit large increases in strength (∼25%) | 2024 doi:10.2337/dci23-0100 |"},{"id":"claim_3","type":"claim","text":"| runners and sedentary group in Stanfor… | sedentary lifestyle | those who exercise had a significantly lower risk of dying (15%) than the sedentary group… | 2021 doi:10.18632/aging.203051 |"},{"id":"claim_4","type":"claim","text":"| general population | sedentary lifestyle | regular physical activity reduces this risk by 24%. | 2021 doi:10.3390/ijms221910260 |"},{"id":"claim_5","type":"claim","text":"| adults at risk for colon cancer | — | Physical activity may prevent approximately 15% of the colon cancers. | 2019 doi:10.4251/wjgo.v11.i5.348 |"},{"id":"claim_6","type":"claim","text":"| adults after dynamic resistance traini… | control | After dynamic resistance training, Vo(2) peak increased by 10.6% (P=0.01) | 2011 doi:10.1161/hypertensionaha.111.177071 |"},{"id":"claim_7","type":"claim","text":"| institutionalized elderly (age 70.88 ±… | control group | Significant increases were observed in the exercise group on cardiorespiratory endurance (… | 2011 doi:10.5402/2012/124916 |"},{"id":"source_1","type":"source","study":"Incretin-Based Weight Loss Pharmacotherapy: Can Resistance Exercise Optimize Changes in Body Composition?","year":2024,"doi":"10.2337/dci23-0100","url":"https://doi.org/10.2337/dci23-0100","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations","year":2022,"doi":"10.2147/dddt.s365416","url":"https://doi.org/10.2147/dddt.s365416","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Selected Methods of Resistance Training for Prevention and Treatment of Sarcopenia","year":2022,"doi":"10.3390/cells11091389","url":"https://doi.org/10.3390/cells11091389","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Effects of exercise on cellular and tissue aging","year":2021,"doi":"10.18632/aging.203051","url":"https://doi.org/10.18632/aging.203051","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Recurrent training rejuvenates and enhances transcriptome and methylome responses in young and older human muscle","year":2021,"doi":"10.1002/rco2.52","url":"https://doi.org/10.1002/rco2.52","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_6","type":"source","study":"Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?","year":2021,"doi":"10.3390/ijms221910260","url":"https://doi.org/10.3390/ijms221910260","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_7","type":"source","study":"Exercise-based cardiac rehabilitation for adults after heart valve surgery","year":2021,"doi":"10.1002/14651858.cd010876.pub3","url":"https://doi.org/10.1002/14651858.cd010876.pub3","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_8","type":"source","study":"Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure","year":2021,"doi":"10.1161/jaha.121.020980","url":"https://doi.org/10.1161/jaha.121.020980","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_9","type":"source","study":"Physical fitness in community‐dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures","year":2020,"doi":"10.1111/acel.13105","url":"https://doi.org/10.1111/acel.13105","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_10","type":"source","study":"Effect of exercise on colorectal cancer prevention and treatment","year":2019,"doi":"10.4251/wjgo.v11.i5.348","url":"https://doi.org/10.4251/wjgo.v11.i5.348","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_11","type":"source","study":"PHAROS—PHysical Assistant RObot System","year":2018,"doi":"10.3390/s18082633","url":"https://doi.org/10.3390/s18082633","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_12","type":"source","study":"Aerobic exercise improves quality of life, psychological well-being and systemic inflammation in subjects with Alzheimer’s disease","year":2017,"doi":"10.4314/ahs.v16i4.22","url":"https://doi.org/10.4314/ahs.v16i4.22","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_13","type":"source","study":"Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms","year":2015,"doi":"10.18632/aging.100789","url":"https://doi.org/10.18632/aging.100789","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_14","type":"source","study":"Physical Exercise as Therapy for Frailty","year":2015,"doi":"10.1159/000382065","url":"https://doi.org/10.1159/000382065","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_15","type":"source","study":"Adherence to exercise and affective responses","year":2014,"doi":"10.1097/gme.0000000000000366","url":"https://doi.org/10.1097/gme.0000000000000366","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_16","type":"source","study":"Molecular Networks of Human Muscle Adaptation to Exercise and Age","year":2013,"doi":"10.1371/journal.pgen.1003389","url":"https://doi.org/10.1371/journal.pgen.1003389","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_17","type":"source","study":"Impact of Resistance Training on Blood Pressure and Other Cardiovascular Risk Factors","year":2011,"doi":"10.1161/hypertensionaha.111.177071","url":"https://doi.org/10.1161/hypertensionaha.111.177071","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_18","type":"source","study":"Effects of Multicomponent Exercise Training on Physical Functioning among Institutionalized Elderly","year":2011,"doi":"10.5402/2012/124916","url":"https://doi.org/10.5402/2012/124916","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"f9eee40c-93ea-461f-b51b-e766983b9da2","to":"claim_1","type":"contains_claim"},{"from":"f9eee40c-93ea-461f-b51b-e766983b9da2","to":"claim_2","type":"contains_claim"},{"from":"f9eee40c-93ea-461f-b51b-e766983b9da2","to":"claim_3","type":"contains_claim"},{"from":"f9eee40c-93ea-461f-b51b-e766983b9da2","to":"claim_4","type":"contains_claim"},{"from":"f9eee40c-93ea-461f-b51b-e766983b9da2","to":"claim_5","type":"contains_claim"},{"from":"f9eee40c-93ea-461f-b51b-e766983b9da2","to":"claim_6","type":"contains_claim"},{"from":"f9eee40c-93ea-461f-b51b-e766983b9da2","to":"claim_7","type":"contains_claim"}],"screening":{"identified":18,"screened":18,"excluded":0,"included":18,"included_or_retained":18,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"18 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}