{"publication_id":"f7aceb24-5650-43e9-8e4f-c8d8c3a376dd","traces":[{"claim_id":"claim_1","claim":"Across retrieved fact-level receipts for fisetin, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]},{"claim_id":"claim_2","claim":"Finding: DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]},{"claim_id":"claim_3","claim":"This receipt-backed scoping note has one bounded signal: fisetin shows endpoint-specific favorable signals with context limits across this 5-source primary bundle (2010-2023). Grouped by direction: directionally favorable: 3 receipt(s) | other/mixed: 2 receipt(s). The source facts cover 5 population context(s) and 4 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete source-level examples: IC50 of fisetin 3.4 ± 0.3 μM on senescent cells versus 7.0 ± 0.4 μM on control cells; DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h; Only quercetin and fisetin inhibited DENV-2 and DENV-3 infection in the absence or presence of enhancing antibody (>90%, p<0.001);.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]},{"claim_id":"claim_4","claim":"null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]},{"claim_id":"claim_5","claim":"directionally favorable: Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells — DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]},{"claim_id":"claim_6","claim":"directionally favorable: &lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt; — Only quercetin and fisetin inhibited DENV-2 and DENV-3 infection in the absence or presence of enhancing antibody (>90%, p<0.001); ( mechanistic ablation supports the topic effect; not a comparator outcome)","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]},{"claim_id":"claim_7","claim":"directionally favorable: Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models — Fisetin treatment significantly inhibited the activation of p38 and JNK, but had enhanced effect on ERK1/2. ( mechanistic ablation supports the topic effect; not a comparator outcome)","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]},{"claim_id":"claim_8","claim":"Specific moderators in this bundle are population/indication (HEKa cells (adult human epidermal keratinocytes); Human U937-DC-SIGN macrophages infected with dengue virus serotypes 2 or 3; PC3 human prostate cancer cells; TNF-α stimulated NHEKs; senescent human umbilical vein endothelial cells (HUVECs)), study design/evidence type (primary).","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]},{"claim_id":"claim_9","claim":"The selected receipts group because each carries a fact-level extraction for fisetin; they separate by context (human clinical/observational and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]},{"claim_id":"claim_10","claim":"The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://doi.org/10.1111/acel.14060"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://doi.org/10.1080/01635581003605524"},{"study":"&lt;p&gt;Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies&lt;/p&gt;","doi":"10.2147/idr.s210890","url":"https://doi.org/10.2147/idr.s210890"},{"study":"Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation","doi":"10.3389/fimmu.2022.1075804","url":"https://doi.org/10.3389/fimmu.2022.1075804"},{"study":"Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models","doi":"10.3390/cells8091089","url":"https://doi.org/10.3390/cells8091089"}]}]}