{"publication_id":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","content_hash":"sha256:1ee5e9f358cec0f3e045d991361af3291b7ebcf1c11b78d38af6d1548ed0a920","nodes":[{"id":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","type":"publication","title":"Bounded Caloric restriction signal: when TRF is combined with caloric restriction, weight loss is >5% of the initial body weight"},{"id":"claim_1","type":"claim","text":"The cited A/B receipts support a specific working claim: when TRF is combined with caloric restriction, weight loss is >5% of the initial body weight; RT reduced 93.5% of CR-induced LBM loss. The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"The non-obvious framing lies in leveraging resistance training to not only preserve lean mass during caloric restriction but also to enhance cardiometabolic outcomes in high-risk populations, bridging the gap between rodent lifespan extensions and human clinical efficacy."},{"id":"claim_4","type":"claim","text":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?"},{"id":"claim_5","type":"claim","text":"`fact_id=162990` (`A_core`) — 30% CR in young male mice decreased fat mass and improved glucose tolerance and insulin sensitivity doi=10.7554/elife.88080"},{"id":"claim_6","type":"claim","text":"_Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._"},{"id":"source_1","type":"source","study":"Effects of Time-Restricted Feeding and Ramadan Fasting on Body Weight, Body Composition, Glucose Responses, and Insulin Resistance: A Systematic Review of Randomized Controlled Trials","year":2022,"doi":"10.3390/nu14224778","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis","year":2018,"doi":"10.3390/nu10040423","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction","year":2022,"doi":"10.1161/circheartfailure.122.010161","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial","year":2023,"doi":"10.1038/s43587-022-00357-y","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","year":2023,"doi":"10.7554/elife.88080","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","to":"claim_1","type":"contains_claim"},{"from":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","to":"claim_2","type":"contains_claim"},{"from":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","to":"claim_3","type":"contains_claim"},{"from":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","to":"claim_4","type":"contains_claim"},{"from":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","to":"claim_5","type":"contains_claim"},{"from":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","to":"claim_6","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}