{"publication_id":"f271139f-9010-4c8e-bab9-67019d5a231a","content_hash":"sha256:f0bec360f45f86d68ce65b2300624203bb66ebf46badd8406eca36d6414eb436","nodes":[{"id":"f271139f-9010-4c8e-bab9-67019d5a231a","type":"publication","title":"Telomere may hinge on a boundary condition"},{"id":"claim_1","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_2","type":"claim","text":"Real tension: the interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition."},{"id":"claim_3","type":"claim","text":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?"},{"id":"claim_4","type":"claim","text":"`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017"},{"id":"claim_5","type":"claim","text":"`fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968"},{"id":"claim_6","type":"claim","text":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"},{"id":"claim_7","type":"claim","text":"_Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._"},{"id":"source_1","type":"source","study":"Telomere length and brain aging: A systematic review and meta-analysis","year":2022,"doi":"10.1016/j.arr.2022.101679","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"Telomere Length and All-Cause Mortality: A Meta-analysis","year":2018,"doi":"10.1016/j.arr.2018.09.002","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","year":2019,"doi":"10.1111/acel.13017","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","year":2017,"doi":"10.1158/1055-9965.epi-16-0968","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_5","type":"source","study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","year":2019,"doi":"10.1164/rccm.201902-0360oc","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_1","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_2","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_3","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_4","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_5","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_6","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_7","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}