{"publication_id":"f0b4aa8b-f260-4fc6-8419-dac0b0a34715","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Movila 2026","doi":"10.3390/ijms27073168","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Borges 2024","doi":"10.1155/2024/6295345","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Jansz 2026","doi":"10.1007/s00125-025-06577-2","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Ali 2026","doi":"10.1007/s00228-025-03985-6","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Cersosimo 2025","doi":"10.2459/JCM.0000000000001733","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Omori 2026","doi":"10.1111/jdi.70240","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Jiang 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public sidecar","directness":"review-level"},{"study":"Chen 2023","doi":"10.3389/fendo.2023.1236404","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"E 2026","doi":"10.1155/jdr/6584068","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Salvatore 2022","doi":"10.3390/ijms23073651","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Neuen 2026","doi":"10.1001/jama.2025.20834","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Cho 2025","doi":"10.1371/journal.pone.0314454","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Daniyal 2026","doi":"10.1002/edm2.70184","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Chen 2026","doi":"10.3390/ijms27020608","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Hu 2026","doi":"10.3389/fmed.2026.1768225","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Schonberger 2023","doi":"10.3390/ijerph20176671","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Joongpan 2026","doi":"10.1002/prp2.70232","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Neuen 2024","doi":"10.1161/circulationaha.124.071689","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Zou 2019","doi":"10.1097/MD.0000000000018245","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Baker 2017","doi":"10.1161/JAHA.117.005686","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Studenski 2011","doi":"10.1001/jama.2010.1923","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Cesari 2009","doi":"10.1093/gerona/glp012","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Cruz-Jentoft 2019","doi":"10.1093/ageing/afy169","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Ioannidis 2005","doi":"10.1371/journal.pmed.0020124","risk_of_bias":"not appraised in public sidecar","directness":"citation"}]}