{"publication_id":"e2acb093-79b1-4513-8106-e291ece5791d","content_hash":"sha256:994dcd29b376ff8f190809df6ff2bf83fe7c0a4d15182f163db43c5030a1bb7d","nodes":[{"id":"e2acb093-79b1-4513-8106-e291ece5791d","type":"publication","title":"Vitamin D healthspan has a live counter-signal"},{"id":"claim_1","type":"claim","text":"The cited receipts show an apparent collision between a positive direct signal in general population (analytical studies) (vitamin D supplementation has a protective effect against the incidence of COVID-19 in analytical studies (OR = 0.592, 95% IC 0.476-0.736)) and an opposing endpoint in adults with chronic liver diseases (We are very uncertain regarding the effect of vitamin D versus placebo or no intervention on all-cause mortality (risk ratio (RR) 0.86, 95% confidence interval (CI) 0.51 to"},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"`fact_id=77927` (`A_core`) — We are very uncertain regarding the effect of vitamin D versus placebo or no intervention on all-cause mortality (risk ratio (RR) 0.86, 95% confidence interval (CI) 0.51 to 1.45; 27 trials; 1979 participants). doi=10.1002/14651858.cd011564.pub3"},{"id":"claim_4","type":"claim","text":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"},{"id":"claim_5","type":"claim","text":"`fact_id=77927` (`A_core`) — We are very uncertain regarding the effect of vitamin D versus placebo or no intervention on all-cause mortality (risk ratio (RR) 0.86, 95% confidence interval (CI) 0.51 to 1.45; 27 trials; 1979 participants). Source: Vitamin D supplementation for chronic liver diseases in adults"},{"id":"claim_6","type":"claim","text":"`fact_id=178491` (`B_context`) — supplementation with 2 000 IU/d of vitamin D did not reduce the risk of total or hip fractures Source: The Effects of Vitamin D Supplementation on Musculoskeletal Health: The VITAL and DO-Health Trials"},{"id":"source_1","type":"source","study":"Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis","year":2024,"doi":"10.3390/nu16050679","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"Vitamin D supplementation for chronic liver diseases in adults","year":2021,"doi":"10.1002/14651858.cd011564.pub3","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Vitamin D and Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Implications—A Narrative Review","year":2025,"doi":"10.3390/ijms26052153","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_4","type":"source","study":"Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases","year":2023,"doi":"10.3390/nu15020334","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Vitamin D and Lung Outcomes in Elderly COVID-19 Patients","year":2021,"doi":"10.3390/nu13030717","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_6","type":"source","study":"Whey Protein Supplementation with or without Vitamin D on Sarcopenia-Related Measures: A Systematic Review and Meta-Analysis","year":2023,"doi":"10.1016/j.advnut.2023.05.011","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_7","type":"source","study":"The Effects of Vitamin D Supplementation on Musculoskeletal Health: The VITAL and DO-Health Trials","year":2023,"doi":"10.1093/gerona/glad073","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"e2acb093-79b1-4513-8106-e291ece5791d","to":"claim_1","type":"contains_claim"},{"from":"e2acb093-79b1-4513-8106-e291ece5791d","to":"claim_2","type":"contains_claim"},{"from":"e2acb093-79b1-4513-8106-e291ece5791d","to":"claim_3","type":"contains_claim"},{"from":"e2acb093-79b1-4513-8106-e291ece5791d","to":"claim_4","type":"contains_claim"},{"from":"e2acb093-79b1-4513-8106-e291ece5791d","to":"claim_5","type":"contains_claim"},{"from":"e2acb093-79b1-4513-8106-e291ece5791d","to":"claim_6","type":"contains_claim"}],"screening":{"identified":7,"screened":7,"excluded":0,"included":7,"included_or_retained":7,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"7 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}