{"publication_id":"d8e97ad6-d465-4e84-8231-2402678c670c","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease","doi":"10.1161/JAHA.125.042610","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone","doi":"10.1111/acel.70457","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)","doi":"10.3390/s24175832","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"The EVA Study: Early Vascular Aging in Women With History of Preeclampsia","doi":"10.1161/JAHA.122.028116","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial","doi":"10.3389/fpubh.2025.1723100","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Accelerated Vascular Aging as a Possible Mechanism of Troponin I Release in the Absence of Clinically Manifested Myocardial Injury","doi":"10.1161/JAHA.124.037718","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials","doi":"10.3389/fnut.2025.1632952","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Relationship between addictions and obesity, physical activity and vascular aging in young adults (EVA-Adic study): a research protocol of a cross-sectional study","doi":"10.3389/fpubh.2024.1322437","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Prevalence and determinants of vascular aging in Austria – a holistic view: the LEAD study","doi":"10.1097/HJH.0000000000004227","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Estimating Vascular Age to Evaluate the Association Between Aging and Cardiovascular Disease","doi":"10.1111/acel.70503","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Vascular Endothelial Function, Carotid Intima–Media Thickness and Coronary Artery Calcification in Women","doi":"10.3390/jcm15114087","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Arterial stiffness in acute decompensated heart failure and acute kidney injury: a prospective observational cohort study protocol in a tertiary hospital setting","doi":"10.1136/bmjopen-2024-097718","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Arterial Age and Early Vascular Aging, But Not Chronological Age, Are Associated With Faster Thoracic Aortic Aneurysm Growth","doi":"10.1161/JAHA.122.029466","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Methylarginine levels and their impact on vascular aging: a systematic review","doi":"10.1530/VB-25-0004","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Advanced vascular aging and outcomes after acute ischemic stroke: a systematic review and meta-analysis.","doi":"10.1038/s41371-024-00961-y","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Studenski 2011","doi":"10.1001/jama.2010.1923","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Cesari 2009","doi":"10.1093/gerona/glp012","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Cruz-Jentoft 2019","doi":"10.1093/ageing/afy169","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Ioannidis 2005","doi":"10.1371/journal.pmed.0020124","risk_of_bias":"not appraised in public sidecar","directness":"citation"}]}