{"publication_id":"d3b70206-291b-45c9-b804-ee73aaf10692","content_hash":"sha256:93c1af19fbb38ba9ed93ea678a911369d0a9b439c8f07049bbc4cd296451a604","nodes":[{"id":"d3b70206-291b-45c9-b804-ee73aaf10692","type":"publication","title":"quercetin: one bounded, context-dependent signal across receipts"},{"id":"claim_1","type":"claim","text":"Across retrieved fact-level receipts for quercetin, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?"},{"id":"claim_2","type":"claim","text":"null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable."},{"id":"claim_3","type":"claim","text":"directionally favorable: Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway — targeted in vivo inhibition or in vitro knockdown of Sirt1 significantly reduced the anti‑ferroptotic functions of quercetin. ( mechanistic ablation supports the topic effect; not a comparator outcome)"},{"id":"claim_4","type":"claim","text":"Specific moderators in this bundle are population/indication (STZ-induced diabetic rats; mice; mouse and cell models; streptozotocin-induced diabetic rats; streptozotocin-nicotinamide (STZ-NA)-induced diabetic mice), study design/evidence type (primary)."},{"id":"claim_5","type":"claim","text":"The selected receipts group because each carries a fact-level extraction for quercetin; they separate by context (animal model) and endpoint, so they are not interchangeable evidence for one pooled claim."},{"id":"claim_6","type":"claim","text":"The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate."},{"id":"source_1","type":"source","study":"Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","year":2012,"doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy","year":2016,"doi":"10.3390/nu8010027","url":"https://doi.org/10.3390/nu8010027","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats","year":2023,"doi":"10.3390/metabo13010130","url":"https://doi.org/10.3390/metabo13010130","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Quercetin and Kaempferol as Multi-Targeting Antidiabetic Agents against Mouse Model of Chemically Induced Type 2 Diabetes","year":2024,"doi":"10.3390/ph17060757","url":"https://doi.org/10.3390/ph17060757","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway","year":2023,"doi":"10.3892/ijmm.2023.5321","url":"https://doi.org/10.3892/ijmm.2023.5321","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"d3b70206-291b-45c9-b804-ee73aaf10692","to":"claim_1","type":"contains_claim"},{"from":"d3b70206-291b-45c9-b804-ee73aaf10692","to":"claim_2","type":"contains_claim"},{"from":"d3b70206-291b-45c9-b804-ee73aaf10692","to":"claim_3","type":"contains_claim"},{"from":"d3b70206-291b-45c9-b804-ee73aaf10692","to":"claim_4","type":"contains_claim"},{"from":"d3b70206-291b-45c9-b804-ee73aaf10692","to":"claim_5","type":"contains_claim"},{"from":"d3b70206-291b-45c9-b804-ee73aaf10692","to":"claim_6","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}