{"publication_id":"cfff5e6e-2337-4f55-95c8-b363344db16a","content_hash":"sha256:79f55f8e1d50168eb9394458e216b5aaaf4a266b1f13faad1a82f950548372c4","nodes":[{"id":"cfff5e6e-2337-4f55-95c8-b363344db16a","type":"publication","title":"Hyperbaric oxygen HBOT: cited direct receipts are heterogeneous"},{"id":"claim_1","type":"claim","text":"The cited direct receipts form a heterogeneous evidence map across Diabetic patients with diabetic foot ulcers (768 participants, 14 studies); patients with nonischemic diabetic foot ulcers; 73 patients with hard-to-heal venous leg ulcers; aging populations, not one integrated effect estimate. Numeric effects in the bundle are source-specific unless another cited receipt repeats the same population, endpoint, comparator, and time window."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"The surprise is the bounded heterogeneity: the cited direct receipts do not support one uniform effect estimate, so the useful alpha is the specific receipt map and its unresolved spread."},{"id":"claim_4","type":"claim","text":"`fact_id=188542` (`A_core`) — T-cytotoxic senescent cell percentages decreased significantly by -10.96%±12.59 (p=0.0004) post-HBOT. doi=10.18632/aging.202188"},{"id":"claim_5","type":"claim","text":"Treat this as a receipt map for choosing the next extraction, not as evidence that the topic has one unified effect. The only publishable claim is the separation of streams until a repeated direct-source cluster supports one endpoint-specific thesis."},{"id":"source_1","type":"source","study":"Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials","year":2021,"doi":"10.1038/s41598-021-81886-1","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"Hyperbaric oxygen therapy for nonischemic diabetic ulcers: A systematic review","year":2019,"doi":"10.1111/wrr.12776","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment","year":2020,"doi":"10.1111/wrr.12853","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial","year":2020,"doi":"10.18632/aging.202188","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Hyperbaric oxygen therapy effectively alleviates D-galactose-induced-age-related cardiac dysfunction via attenuating mitochondrial dysfunction in pre-diabetic rats","year":2021,"doi":"10.18632/aging.202970","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"cfff5e6e-2337-4f55-95c8-b363344db16a","to":"claim_1","type":"contains_claim"},{"from":"cfff5e6e-2337-4f55-95c8-b363344db16a","to":"claim_2","type":"contains_claim"},{"from":"cfff5e6e-2337-4f55-95c8-b363344db16a","to":"claim_3","type":"contains_claim"},{"from":"cfff5e6e-2337-4f55-95c8-b363344db16a","to":"claim_4","type":"contains_claim"},{"from":"cfff5e6e-2337-4f55-95c8-b363344db16a","to":"claim_5","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}