{"publication_id":"bde27e52-8cfd-4e9f-8721-e899352f3a58","traces":[{"claim_id":"claim_1","claim":"Across retrieved source-level receipts for acarbose, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?","candidate_sources":[{"source_id":"source_1","study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","support_kind":"candidate_source_row","population":"female mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","support_kind":"candidate_source_row","population":"HET3 mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_3","study":"Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","support_kind":"candidate_source_row","population":"maltose loaded diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","doi":"10.1128/msphere.00528-18","url":"https://doi.org/10.1128/msphere.00528-18","support_kind":"candidate_source_row","population":"mice fed high-starch diet","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic rats","endpoint":"not 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mono- and disaccharides challenge in normal and diabetic rats","doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","support_kind":"candidate_source_row","population":"maltose loaded diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","doi":"10.1128/msphere.00528-18","url":"https://doi.org/10.1128/msphere.00528-18","support_kind":"candidate_source_row","population":"mice fed high-starch diet","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic rats","endpoint":"not extracted","effect":"not 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on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","support_kind":"candidate_source_row","population":"maltose loaded diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","doi":"10.1128/msphere.00528-18","url":"https://doi.org/10.1128/msphere.00528-18","support_kind":"candidate_source_row","population":"mice fed high-starch diet","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic 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rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_7","claim":"| Outcome family | Receipt | Evidence role | Population/setting | Metric | Extracted finding |","candidate_sources":[{"source_id":"source_1","study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","support_kind":"candidate_source_row","population":"female mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","support_kind":"candidate_source_row","population":"HET3 mice","endpoint":"not extracted","effect":"not 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Evidence role grouping: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support. The source facts cover 5 population/setting context(s) and 3 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete contrast: other/mixed: Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging: acarbose and 17-α estradiol do not strongly alter these phenotypes; directionally favorable: Acarbose improves health and lifespan in aging HET3 mice: significantly increased (3%) in females only at 1,000 ppm.","candidate_sources":[{"source_id":"source_1","study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","support_kind":"candidate_source_row","population":"female mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","support_kind":"candidate_source_row","population":"HET3 mice","endpoint":"not extracted","effect":"not 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extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_14","claim":"Specific moderators in this bundle are population/indication (HET3 mice; diabetic rats; female mice; maltose loaded diabetic rats; mice fed high-starch diet), study design/evidence type (primary).","candidate_sources":[{"source_id":"source_1","study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","support_kind":"candidate_source_row","population":"female mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","support_kind":"candidate_source_row","population":"HET3 mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_3","study":"Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","support_kind":"candidate_source_row","population":"maltose loaded diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","doi":"10.1128/msphere.00528-18","url":"https://doi.org/10.1128/msphere.00528-18","support_kind":"candidate_source_row","population":"mice fed high-starch diet","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_15","claim":"Population/settings are separated as receipt context: HET3 mice, diabetic rats, female mice, maltose loaded diabetic rats, and mice fed high-starch diet. The selected receipts group because each carries a fact-level extraction for acarbose; they separate by context (animal model) and endpoint, so they are not interchangeable evidence for one pooled claim.","candidate_sources":[{"source_id":"source_1","study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","support_kind":"candidate_source_row","population":"female mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","support_kind":"candidate_source_row","population":"HET3 mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_3","study":"Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","support_kind":"candidate_source_row","population":"maltose loaded diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","doi":"10.1128/msphere.00528-18","url":"https://doi.org/10.1128/msphere.00528-18","support_kind":"candidate_source_row","population":"mice fed high-starch diet","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_16","claim":"The signal is purely descriptive of source-level direction and scope; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.","candidate_sources":[{"source_id":"source_1","study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","support_kind":"candidate_source_row","population":"female mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","support_kind":"candidate_source_row","population":"HET3 mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_3","study":"Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","support_kind":"candidate_source_row","population":"maltose loaded diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","doi":"10.1128/msphere.00528-18","url":"https://doi.org/10.1128/msphere.00528-18","support_kind":"candidate_source_row","population":"mice fed high-starch diet","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]}]}