{"publication_id":"bd4ddec9-e10e-445f-bf0b-a5399dfae223","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Jongsma 2023","doi":"10.1093/ecco-jcc/jjad049","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Xie 2025","doi":"10.1038/s41392-025-02252-5","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Wallen 2024","doi":"10.3389/fimmu.2024.1413956","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Hoang 2025","doi":"10.1038/s44319-025-00516-3","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Boudhabhay 2026","doi":"10.1016/j.ekir.2025.103766","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Nakanjako 2024","doi":"10.1016/j.heliyon.2024.e31910","risk_of_bias":"not appraised in public 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sidecar","directness":"primary"},{"study":"Karakaslar 2023","doi":"10.1111/acel.13792","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Shin 2022","doi":"10.1111/acel.13702","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Brode 2025","doi":"10.3390/biom16010055","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Qing 2024","doi":"10.1007/s00277-023-05603-w","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Ma 2026","doi":"10.3389/fimmu.2026.1742646","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Samuelsen 2024","doi":"10.1097/CCE.0000000000001106","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Qu 2022","doi":"10.1038/s41390-022-02203-8","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Hu 2024","doi":"10.1038/s41467-024-52522-z","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Govind 2024","doi":"10.1186/s12979-024-00490-9","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Roy 2023","doi":"10.7554/eLife.86136","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Brode 2023","doi":"10.3390/ijms241713186","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Liu 2023","doi":"10.1097/HEP.0000000000000590","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Le 2025","doi":"10.3390/cells14221793","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Peronnet 2023","doi":"10.1097/CCM.0000000000005832","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Noppert 2025","doi":"10.1093/geroni/igaf122.2016","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Rousseau 2025","doi":"10.1186/s12929-025-01146-6","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Kapse 2024","doi":"10.3389/frtra.2024.1356948","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Noppert 2023","doi":"10.1093/geroni/igad104.1007","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Aitella 2026","doi":"10.3390/ijms27031206","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Zhang 2025","doi":"10.1136/jitc-2025-012432","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Ioannidis 2005","doi":"10.1371/journal.pmed.0020124","risk_of_bias":"not appraised in public sidecar","directness":"citation"}]}