{"publication_id":"b64067ab-fff7-4920-b478-43d193aadc87","content_hash":"sha256:94e56f6f6f236484d2037e72d82b6946966f24acd8b08e034e1aae9deee2fb27","nodes":[{"id":"b64067ab-fff7-4920-b478-43d193aadc87","type":"publication","title":"Alpha memo: resveratrol exercise signal"},{"id":"claim_1","type":"claim","text":"One-sentence alpha:** resveratrol / exercise does not carry one stable direction across the two receipts; the supported alpha is an endpoint- and setting-bounded comparison rather than a universal benefit or harm claim."},{"id":"claim_2","type":"claim","text":"Synthesis:** Receipt 1 reports Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats in an animal model. Receipt 2 reports Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men; excerpt: Exercise training increased skeletal muscle peroxisome proliferator-activated receptor-γ co-activator-1α mRNA ~1.5-fold, cytochrome c protein ~1.3-fold, cytochrome c oxidase I protein ~1.5-fold, citrate synthase activity ~1.3-fold, 3-hydrox in a human study. The comparison is bounded to resveratrol / exercise, and should not be read as advice, settled science, or a broad class claim."},{"id":"claim_3","type":"claim","text":"Interpretation:** The supported claim is not universal failure; it is that the Receipt 1 signal does not automatically transfer to the Receipt 2 population, modality, and endpoint bundle."},{"id":"claim_4","type":"claim","text":"Evidence gap:** The missing study is one matched design with the same population, protocol, dose, duration, and endpoint."},{"id":"source_1","type":"source","study":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","year":2012,"doi":"10.1113/jphysiol.2012.230490","url":"https://www.semanticscholar.org/paper/55611be306e3abdce30150fde45b4fc327435317","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men","year":2014,"doi":"10.1113/jphysiol.2013.270256","url":"https://doi.org/10.1113/jphysiol.2013.270256","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"b64067ab-fff7-4920-b478-43d193aadc87","to":"claim_1","type":"contains_claim"},{"from":"b64067ab-fff7-4920-b478-43d193aadc87","to":"claim_2","type":"contains_claim"},{"from":"b64067ab-fff7-4920-b478-43d193aadc87","to":"claim_3","type":"contains_claim"},{"from":"b64067ab-fff7-4920-b478-43d193aadc87","to":"claim_4","type":"contains_claim"}],"screening":{"identified":2,"screened":2,"excluded":0,"included":2,"included_or_retained":2,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"2 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}