{"publication_id":"acbf1c12-fb9c-49dc-8bc1-caa5a119a8cf","content_hash":"sha256:2be08c16e36e91122da81bdc3cb28b7b7511551b71b4cc4770d721c9e2fc308c","nodes":[{"id":"acbf1c12-fb9c-49dc-8bc1-caa5a119a8cf","type":"publication","title":"Alpha memo: resveratrol blunts exercise training"},{"id":"claim_1","type":"claim","text":"One-sentence alpha:** Resveratrol may modestly reduce some exercise-induced cardiovascular gains in older men, but the evidence does not support claims of broadly negative or harmful effects."},{"id":"claim_2","type":"claim","text":"Receipt 2:** \"Recent data do not provide evidence that resveratrol causes 'mainly negative' or 'adverse' effects on exercise training in humans\" (same journal, 2013) reanalyzes Gliemann et al. and finds that of ~45 variables examined, exercise training improved 12 variables and did not worsen others, concluding the original framing as \"adverse\" is not supported by the data shown."},{"id":"claim_3","type":"claim","text":"Why this is surprising:** The original paper's running head implies resveratrol counteracts exercise benefits, but the more granular re-examination suggests the blunting signal is narrow and may not generalize to a broader adverse-effect claim, meaning a single anchor (\"blunts\") can overstate the true effect direction."},{"id":"source_1","type":"source","study":"Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men","year":2013,"doi":"10.1113/jphysiol.2013.258061","url":"https://doi.org/10.1113/jphysiol.2013.258061","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Recent data do not provide evidence that resveratrol causes ‘mainly negative’ or ‘adverse’ effects on exercise training in humans","year":2013,"doi":"10.1113/jphysiol.2013.262956","url":"https://doi.org/10.1113/jphysiol.2013.262956","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"acbf1c12-fb9c-49dc-8bc1-caa5a119a8cf","to":"claim_1","type":"contains_claim"},{"from":"acbf1c12-fb9c-49dc-8bc1-caa5a119a8cf","to":"claim_2","type":"contains_claim"},{"from":"acbf1c12-fb9c-49dc-8bc1-caa5a119a8cf","to":"claim_3","type":"contains_claim"}],"screening":{"identified":2,"screened":2,"excluded":0,"included":2,"included_or_retained":2,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"2 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}