{"publication_id":"ab40c73a-dca5-4102-8b82-441a90f13b37","traces":[{"claim_id":"claim_1","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.","candidate_sources":[{"study":"Use of metformin and survival of patients with high‐grade glioma","doi":"10.1002/ijc.31783","url":null},{"study":"Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study","doi":"10.3389/fmed.2021.640785","url":null},{"study":"Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis","doi":"10.3389/fmed.2021.704666","url":null},{"study":"Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review","doi":"10.1016/j.aohep.2019.10.005","url":null},{"study":"Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer","doi":"10.1111/acel.12496","url":null}]},{"claim_id":"claim_2","claim":"`fact_id=166319` (`A_core`) — Metformin (0.1%) combined with rapamycin (14 ppm) robustly extended lifespan, suggestive of an added benefit. doi=10.1111/acel.12496","candidate_sources":[{"study":"Use of metformin and survival of patients with high‐grade glioma","doi":"10.1002/ijc.31783","url":null},{"study":"Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study","doi":"10.3389/fmed.2021.640785","url":null},{"study":"Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis","doi":"10.3389/fmed.2021.704666","url":null},{"study":"Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review","doi":"10.1016/j.aohep.2019.10.005","url":null},{"study":"Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer","doi":"10.1111/acel.12496","url":null}]}]}