{"publication_id":"a2d1bd44-d221-428e-b691-ad49f3c24335","content_hash":"sha256:2c30b6688ea6355c650cd7727e851b8158afbc870b4a0d47640f851157cb680b","nodes":[{"id":"a2d1bd44-d221-428e-b691-ad49f3c24335","type":"publication","title":"Rapamycin: evidence map — 5 findings across 5 sources"},{"id":"claim_1","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_2","type":"claim","text":"_No direct opposing receipt was selected by this run. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._"},{"id":"source_1","type":"source","study":"Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction","year":2014,"doi":"10.1111/acel.12194","url":"https://pubmed.ncbi.nlm.nih.gov/24472261/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice","year":2009,"doi":"10.1038/nature08221","url":"https://pubmed.ncbi.nlm.nih.gov/19587680/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer","year":2016,"doi":"10.1111/acel.12496","url":"https://pubmed.ncbi.nlm.nih.gov/27312235/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice","year":2016,"doi":"10.7554/eLife.16351","url":"https://pubmed.ncbi.nlm.nih.gov/27549339/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity.","year":2025,"doi":"10.7759/cureus.98514","url":"https://pubmed.ncbi.nlm.nih.gov/41497909/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"a2d1bd44-d221-428e-b691-ad49f3c24335","to":"claim_1","type":"contains_claim"},{"from":"a2d1bd44-d221-428e-b691-ad49f3c24335","to":"claim_2","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}