{"publication_id":"a180a3d8-5507-45cc-bde8-fb3c07f8c393","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Efficacy and safety of once‐weekly semaglutide 2.4 mg for weight management in participants from China: A prespecified analysis of the STEP 7 randomized clinical trial","doi":"10.1111/dom.16253","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Once-weekly IcoSema versus once-weekly semaglutide in adults with type 2 diabetes: the COMBINE 2 randomised clinical trial","doi":"10.1007/s00125-024-06348-5","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Efficacy and safety of once‐weekly semaglutide in Japanese individuals with type 2 diabetes by baseline age and body mass index","doi":"10.1111/jdi.13773","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity","doi":"10.1111/dom.14280","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Efficacy and safety of once‐weekly semaglutide in Japanese individuals with type 2 diabetes in the SUSTAIN 1, 2, 5 and 9 trials: Post‐hoc analysis","doi":"10.1111/jdi.13905","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Once-Weekly Semaglutide in Patients with Cardiovascular-Kidney-Metabolic Syndrome: A Real-World Study","doi":"10.3390/ph19040583","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Once‐Weekly Semaglutide Versus Once‐Daily Liraglutide for Weight Loss in Adults: A Meta‐Analysis of Randomized Controlled Trials","doi":"10.1111/cts.70127","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Effectiveness and safety of once-weekly semaglutide: findings from the SEMACOL-REAL retrospective multicentric observational study in Colombia","doi":"10.3389/fendo.2024.1372992","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Once-Weekly Semaglutide in Adults With Alcohol Use Disorder","doi":"10.1001/jamapsychiatry.2024.4789","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Once-Weekly Semaglutide in Adults With Daily Cigarette Use","doi":"10.1001/jamanetworkopen.2026.14898","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","doi":"10.1016/j.amjcard.2024.04.041","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg for the management of overweight or obesity in Asian populations: A systematic review, meta-analysis and meta-regression of randomised trials.","doi":"10.1111/dom.70073","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Efficacy and Safety of Once-Weekly Subcutaneous Semaglutide in Overweight or Obese Adults: A Systematic Review with Meta-Analysis.","doi":"10.1055/a-2303-8558","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Once-Weekly Semaglutide in Adolescents with Obesity.","doi":"10.1056/nejmoa2208601","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Efficacy of Semaglutide s.c. Once-weekly on Weight Loss and Management in Adolescents With Monogenic Obesity in Clinical Practice","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis.","doi":"10.1056/nejmoa2403664","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Effect of semaglutide 2.4 mg once weekly on 10-year type 2 diabetes risk in adults with overweight or obesity.","doi":"10.1002/oby.23842","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Cardiovascular risk reduction with once-weekly semaglutide in subjects with type 2 diabetes: a post hoc analysis of gender, age, and baseline CV risk profile in the SUSTAIN 6 trial","doi":"10.1186/s12933-019-0871-8","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity","doi":"10.1111/dom.12932","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial","doi":"10.2337/dc17-0417","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"**Ioannidis 2005.** _Ioannidis JPA. Why most published research findings are false. PLoS Med. 2005;2(8):e124._ DOI: 10.1371/journal.pmed.0020124. PMID: 16060722.","doi":"10.1371/journal.pmed.0020124","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"**WHO 2000.** _World Health Organization. Obesity: Preventing and Managing the Global Epidemic. WHO Technical Report Series 894. 2000._ PMID: 11234459.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Efficacy of Semaglutide S 2028","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"}]}