{"publication_id":"9fd402e5-02e8-4ac2-acd2-1c6bf571b6e5","traces":[{"claim_id":"claim_1","claim":"What evidence fronts does fisetin occupy across animal model, cell or in-vitro model, and chemistry/formulation, and what remains untested?","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://pubmed.ncbi.nlm.nih.gov/38062873/"},{"study":"Improving solubility of fisetin by cocrystallization","doi":"10.1039/c4ce01713g","url":null},{"study":"Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells","doi":"10.3390/ijms18040852","url":"https://pubmed.ncbi.nlm.nih.gov/28420170/"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://pubmed.ncbi.nlm.nih.gov/20574928/"},{"study":"Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle","doi":"10.18632/aging.204275","url":"https://pubmed.ncbi.nlm.nih.gov/36084954/"}]},{"claim_id":"claim_2","claim":"Finding: DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://pubmed.ncbi.nlm.nih.gov/38062873/"},{"study":"Improving solubility of fisetin by cocrystallization","doi":"10.1039/c4ce01713g","url":null},{"study":"Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells","doi":"10.3390/ijms18040852","url":"https://pubmed.ncbi.nlm.nih.gov/28420170/"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://pubmed.ncbi.nlm.nih.gov/20574928/"},{"study":"Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle","doi":"10.18632/aging.204275","url":"https://pubmed.ncbi.nlm.nih.gov/36084954/"}]},{"claim_id":"claim_3","claim":"Answer: this 5-source primary bundle supports a receipt-backed scoping note for fisetin, spanning 2010-2023. The source facts cover 5 population context(s) and 5 intervention/exposure context(s). The bounded signal is context separation across animal model, cell or in-vitro model, and chemistry/formulation: the bundle identifies what has been measured and where the evidence separates, without establishing a causal, clinical, species-translated, or mechanistically integrated intervention claim. Representative source-extracted findings include: IC50 of fisetin 3.4 ± 0.3 μM on senescent cells versus 7.0 ± 0.4 μM on control cells; a 2.5-fold increase of fisetin solubility was achieved for FisNam; Fisetin (<20 µM) restored cell viability and repressed apoptosis, autophagy and ROS production in Tm-treated cells.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://pubmed.ncbi.nlm.nih.gov/38062873/"},{"study":"Improving solubility of fisetin by cocrystallization","doi":"10.1039/c4ce01713g","url":null},{"study":"Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells","doi":"10.3390/ijms18040852","url":"https://pubmed.ncbi.nlm.nih.gov/28420170/"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://pubmed.ncbi.nlm.nih.gov/20574928/"},{"study":"Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle","doi":"10.18632/aging.204275","url":"https://pubmed.ncbi.nlm.nih.gov/36084954/"}]},{"claim_id":"claim_4","claim":"The selected receipts group because each carries a fact-level extraction for fisetin; they separate by context (animal model, cell or in-vitro model, and chemistry/formulation), so they are not interchangeable evidence for one endpoint.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://pubmed.ncbi.nlm.nih.gov/38062873/"},{"study":"Improving solubility of fisetin by cocrystallization","doi":"10.1039/c4ce01713g","url":null},{"study":"Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells","doi":"10.3390/ijms18040852","url":"https://pubmed.ncbi.nlm.nih.gov/28420170/"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://pubmed.ncbi.nlm.nih.gov/20574928/"},{"study":"Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle","doi":"10.18632/aging.204275","url":"https://pubmed.ncbi.nlm.nih.gov/36084954/"}]},{"claim_id":"claim_5","claim":"Source-literature boundary for fisetin: the listed sources define separate evidence fronts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources.","candidate_sources":[{"study":"Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence","doi":"10.1111/acel.14060","url":"https://pubmed.ncbi.nlm.nih.gov/38062873/"},{"study":"Improving solubility of fisetin by cocrystallization","doi":"10.1039/c4ce01713g","url":null},{"study":"Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells","doi":"10.3390/ijms18040852","url":"https://pubmed.ncbi.nlm.nih.gov/28420170/"},{"study":"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells","doi":"10.1080/01635581003605524","url":"https://pubmed.ncbi.nlm.nih.gov/20574928/"},{"study":"Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle","doi":"10.18632/aging.204275","url":"https://pubmed.ncbi.nlm.nih.gov/36084954/"}]}]}