{"publication_id":"9be40a10-b14d-4e4a-afff-f058a818c80b","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial","doi":"10.1016/j.eclinm.2025.103633","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial","doi":"10.1002/lary.70173","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"Nicotinamide riboside with pterostilbene (NRPT) increases NAD + in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI","doi":"10.1186/s12882-020-02006-1","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial","doi":"10.1007/s40256-025-00764-7","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"NAD + -Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults","doi":"10.1093/jn/nxab193","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination","doi":"10.1038/s41598-024-63031-w","risk_of_bias":"not appraised in public sidecar","directness":"indirect"},{"study":"A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD + Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial","doi":"10.3390/nu14112219","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"Effect of C242T Polymorphism in the Gene Encoding the NAD(P)H Oxidase p22 phox Subunit and Aerobic Fitness Levels on Redox State Biomarkers and DNA Damage Responses to Exhaustive Exercise: A Randomized Trial","doi":"10.3390/ijerph17124215","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"A combination of ketones and NAD + precursor preserves white matter integrity in mild cognitive impairment","doi":"10.1002/trc2.70278","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial","doi":"10.1038/s41598-023-29787-3","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"Effects of Nicotinamide Adenine Dinucleotide on Older Patients with Heart Failure","doi":"10.31083/j.rcm2508297","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"Oral MIB‐626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalized Patients With COVID‐19 and Acute Kidney Injury: A Randomized Controlled Trial","doi":"10.1096/fba.2025-00014","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"Comparative lipidomics and NAD⁺ metabolism in pectoris muscle reveal a lean metabolic phenotype in Daweishan miniature chickens versus arbor acre broilers","doi":"10.1016/j.psj.2026.106931","risk_of_bias":"not appraised in public sidecar","directness":"indirect"},{"study":"Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin","doi":"10.1111/acel.13754","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers","doi":"10.1371/journal.pone.0186459","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults","doi":"10.1038/s41467-018-03421-7","risk_of_bias":"not appraised in public sidecar","directness":"direct"},{"study":"Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures","doi":"10.1016/j.celrep.2019.07.043","risk_of_bias":"not appraised in public sidecar","directness":"direct"}]}