{"publication_id":"966edf82-6b1e-4214-8625-15d80ed50795","content_hash":"sha256:f40254a5b23aaa27f98de0047b938bb7d35832060758f788d1ee271633773f19","nodes":[{"id":"966edf82-6b1e-4214-8625-15d80ed50795","type":"publication","title":"Bounded Hyperbaric oxygen HBOT signal: Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT"},{"id":"claim_1","type":"claim","text":"The cited A/B receipts support a specific working claim: Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT; There was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT. The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"`fact_id=188537` (`A_core`) — Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT. doi=10.18632/aging.202188"},{"id":"claim_4","type":"claim","text":"`fact_id=188541` (`A_core`) — There was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT. doi=10.18632/aging.202188"},{"id":"claim_5","type":"claim","text":"`fact_id=188542` (`A_core`) — T-cytotoxic senescent cell percentages decreased significantly by -10.96%±12.59 (p=0.0004) post-HBOT. doi=10.18632/aging.202188"},{"id":"claim_6","type":"claim","text":"`fact_id=187991` (`A_core`) — HBOT increased the total efficacy rate (TEF) (OR = 4.84, 95% CI = 3.19-7.33, P < 0.00001) doi=10.3389/fnagi.2019.00086"},{"id":"source_1","type":"source","study":"Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial","year":2020,"doi":"10.18632/aging.202188","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials","year":2021,"doi":"10.1038/s41598-021-81886-1","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia","year":2019,"doi":"10.3389/fnagi.2019.00086","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_4","type":"source","study":"Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment","year":2020,"doi":"10.1111/wrr.12853","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Hyperbaric oxygen therapy for nonischemic diabetic ulcers: A systematic review","year":2019,"doi":"10.1111/wrr.12776","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"}],"edges":[{"from":"966edf82-6b1e-4214-8625-15d80ed50795","to":"claim_1","type":"contains_claim"},{"from":"966edf82-6b1e-4214-8625-15d80ed50795","to":"claim_2","type":"contains_claim"},{"from":"966edf82-6b1e-4214-8625-15d80ed50795","to":"claim_3","type":"contains_claim"},{"from":"966edf82-6b1e-4214-8625-15d80ed50795","to":"claim_4","type":"contains_claim"},{"from":"966edf82-6b1e-4214-8625-15d80ed50795","to":"claim_5","type":"contains_claim"},{"from":"966edf82-6b1e-4214-8625-15d80ed50795","to":"claim_6","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}