{"publication_id":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","content_hash":"sha256:98b991c70ca5aa0d84c4006a6bff07639c8559468550a2a1bca90754fa2fc977","nodes":[{"id":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","type":"publication","title":"Caloric restriction modulates metabolic and endocrine biomarkers (IGF-1, FGF-21, glucose tolerance) in rodents"},{"id":"claim_1","type":"claim","text":"Across 4 independently cited sources, the evidence converges on one bounded claim: caloric restriction modulates metabolic and endocrine biomarkers (IGF-1, FGF-21, glucose tolerance) in rodents. Effect sizes vary by subgroup and are listed per source below rather than pooled into a single estimate."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"The surprise is the bounded heterogeneity: the cited direct receipts do not support one uniform effect estimate, so the useful alpha is the specific receipt map and its unresolved spread."},{"id":"claim_4","type":"claim","text":"`fact_id=162990` (`A_core`) — 30% CR in young male mice decreased fat mass and improved glucose tolerance and insulin sensitivity doi=10.7554/elife.88080"},{"id":"claim_5","type":"claim","text":"`fact_id=3904` (`A_core`) — proteome half-lives of old hearts significantly increased after short-term CR (30%) doi=10.1111/acel.12203"},{"id":"claim_6","type":"claim","text":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"},{"id":"claim_7","type":"claim","text":"Treat this as a receipt map for choosing the next extraction, not as evidence that the topic has one unified effect. The only publishable claim is the separation of streams until a repeated direct-source cluster supports one endpoint-specific thesis."},{"id":"claim_8","type":"claim","text":"_No direct opposing receipt was selected by this run. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._"},{"id":"source_1","type":"source","study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","year":2023,"doi":"10.7554/elife.88080","url":"https://pubmed.ncbi.nlm.nih.gov/37096321/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart","year":2014,"doi":"10.1111/acel.12203","url":"https://pubmed.ncbi.nlm.nih.gov/24612461/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.","year":2012,"doi":"10.1139/h2012-091","url":"https://pubmed.ncbi.nlm.nih.gov/22891896/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Caloric restriction leads to high marrow adiposity and low bone mass in growing mice","year":2010,"doi":"10.1002/jbmr.82","url":"https://pubmed.ncbi.nlm.nih.gov/20229598/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","year":2022,"doi":"10.1126/science.abk0297","url":"https://pubmed.ncbi.nlm.nih.gov/35511946/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","to":"claim_1","type":"contains_claim"},{"from":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","to":"claim_2","type":"contains_claim"},{"from":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","to":"claim_3","type":"contains_claim"},{"from":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","to":"claim_4","type":"contains_claim"},{"from":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","to":"claim_5","type":"contains_claim"},{"from":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","to":"claim_6","type":"contains_claim"},{"from":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","to":"claim_7","type":"contains_claim"},{"from":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","to":"claim_8","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}