{"publication_id":"9071bd4f-9969-4a7f-85ee-ae7c64682a16","traces":[{"claim_id":"claim_1","claim":"Across 4 independently cited sources, the evidence converges on one bounded claim: caloric restriction modulates metabolic and endocrine biomarkers (IGF-1, FGF-21, glucose tolerance) in rodents. Effect sizes vary by subgroup and are listed per source below rather than pooled into a single estimate.","candidate_sources":[{"study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","doi":"10.7554/elife.88080","url":"https://pubmed.ncbi.nlm.nih.gov/37096321/"},{"study":"Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart","doi":"10.1111/acel.12203","url":"https://pubmed.ncbi.nlm.nih.gov/24612461/"},{"study":"Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.","doi":"10.1139/h2012-091","url":"https://pubmed.ncbi.nlm.nih.gov/22891896/"},{"study":"Caloric restriction leads to high marrow adiposity and low bone mass in growing mice","doi":"10.1002/jbmr.82","url":"https://pubmed.ncbi.nlm.nih.gov/20229598/"},{"study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","doi":"10.1126/science.abk0297","url":"https://pubmed.ncbi.nlm.nih.gov/35511946/"}]},{"claim_id":"claim_2","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.","candidate_sources":[{"study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","doi":"10.7554/elife.88080","url":"https://pubmed.ncbi.nlm.nih.gov/37096321/"},{"study":"Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart","doi":"10.1111/acel.12203","url":"https://pubmed.ncbi.nlm.nih.gov/24612461/"},{"study":"Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.","doi":"10.1139/h2012-091","url":"https://pubmed.ncbi.nlm.nih.gov/22891896/"},{"study":"Caloric restriction leads to high marrow adiposity and low bone mass in growing mice","doi":"10.1002/jbmr.82","url":"https://pubmed.ncbi.nlm.nih.gov/20229598/"},{"study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","doi":"10.1126/science.abk0297","url":"https://pubmed.ncbi.nlm.nih.gov/35511946/"}]},{"claim_id":"claim_3","claim":"The surprise is the bounded heterogeneity: the cited direct receipts do not support one uniform effect estimate, so the useful alpha is the specific receipt map and its unresolved spread.","candidate_sources":[{"study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","doi":"10.7554/elife.88080","url":"https://pubmed.ncbi.nlm.nih.gov/37096321/"},{"study":"Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart","doi":"10.1111/acel.12203","url":"https://pubmed.ncbi.nlm.nih.gov/24612461/"},{"study":"Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.","doi":"10.1139/h2012-091","url":"https://pubmed.ncbi.nlm.nih.gov/22891896/"},{"study":"Caloric restriction leads to high marrow adiposity and low bone mass in growing mice","doi":"10.1002/jbmr.82","url":"https://pubmed.ncbi.nlm.nih.gov/20229598/"},{"study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","doi":"10.1126/science.abk0297","url":"https://pubmed.ncbi.nlm.nih.gov/35511946/"}]},{"claim_id":"claim_4","claim":"`fact_id=162990` (`A_core`) — 30% CR in young male mice decreased fat mass and improved glucose tolerance and insulin sensitivity doi=10.7554/elife.88080","candidate_sources":[{"study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","doi":"10.7554/elife.88080","url":"https://pubmed.ncbi.nlm.nih.gov/37096321/"},{"study":"Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart","doi":"10.1111/acel.12203","url":"https://pubmed.ncbi.nlm.nih.gov/24612461/"},{"study":"Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.","doi":"10.1139/h2012-091","url":"https://pubmed.ncbi.nlm.nih.gov/22891896/"},{"study":"Caloric restriction leads to high marrow adiposity and low bone mass in growing mice","doi":"10.1002/jbmr.82","url":"https://pubmed.ncbi.nlm.nih.gov/20229598/"},{"study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","doi":"10.1126/science.abk0297","url":"https://pubmed.ncbi.nlm.nih.gov/35511946/"}]},{"claim_id":"claim_5","claim":"`fact_id=3904` (`A_core`) — proteome half-lives of old hearts significantly increased after short-term CR (30%) doi=10.1111/acel.12203","candidate_sources":[{"study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","doi":"10.7554/elife.88080","url":"https://pubmed.ncbi.nlm.nih.gov/37096321/"},{"study":"Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart","doi":"10.1111/acel.12203","url":"https://pubmed.ncbi.nlm.nih.gov/24612461/"},{"study":"Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.","doi":"10.1139/h2012-091","url":"https://pubmed.ncbi.nlm.nih.gov/22891896/"},{"study":"Caloric restriction leads to high marrow adiposity and low bone mass in growing mice","doi":"10.1002/jbmr.82","url":"https://pubmed.ncbi.nlm.nih.gov/20229598/"},{"study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","doi":"10.1126/science.abk0297","url":"https://pubmed.ncbi.nlm.nih.gov/35511946/"}]},{"claim_id":"claim_6","claim":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._","candidate_sources":[{"study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","doi":"10.7554/elife.88080","url":"https://pubmed.ncbi.nlm.nih.gov/37096321/"},{"study":"Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart","doi":"10.1111/acel.12203","url":"https://pubmed.ncbi.nlm.nih.gov/24612461/"},{"study":"Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.","doi":"10.1139/h2012-091","url":"https://pubmed.ncbi.nlm.nih.gov/22891896/"},{"study":"Caloric restriction leads to high marrow adiposity and low bone mass in growing mice","doi":"10.1002/jbmr.82","url":"https://pubmed.ncbi.nlm.nih.gov/20229598/"},{"study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","doi":"10.1126/science.abk0297","url":"https://pubmed.ncbi.nlm.nih.gov/35511946/"}]},{"claim_id":"claim_7","claim":"Treat this as a receipt map for choosing the next extraction, not as evidence that the topic has one unified effect. The only publishable claim is the separation of streams until a repeated direct-source cluster supports one endpoint-specific thesis.","candidate_sources":[{"study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","doi":"10.7554/elife.88080","url":"https://pubmed.ncbi.nlm.nih.gov/37096321/"},{"study":"Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart","doi":"10.1111/acel.12203","url":"https://pubmed.ncbi.nlm.nih.gov/24612461/"},{"study":"Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.","doi":"10.1139/h2012-091","url":"https://pubmed.ncbi.nlm.nih.gov/22891896/"},{"study":"Caloric restriction leads to high marrow adiposity and low bone mass in growing mice","doi":"10.1002/jbmr.82","url":"https://pubmed.ncbi.nlm.nih.gov/20229598/"},{"study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","doi":"10.1126/science.abk0297","url":"https://pubmed.ncbi.nlm.nih.gov/35511946/"}]},{"claim_id":"claim_8","claim":"_No direct opposing receipt was selected by this run. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._","candidate_sources":[{"study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","doi":"10.7554/elife.88080","url":"https://pubmed.ncbi.nlm.nih.gov/37096321/"},{"study":"Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart","doi":"10.1111/acel.12203","url":"https://pubmed.ncbi.nlm.nih.gov/24612461/"},{"study":"Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction.","doi":"10.1139/h2012-091","url":"https://pubmed.ncbi.nlm.nih.gov/22891896/"},{"study":"Caloric restriction leads to high marrow adiposity and low bone mass in growing mice","doi":"10.1002/jbmr.82","url":"https://pubmed.ncbi.nlm.nih.gov/20229598/"},{"study":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice","doi":"10.1126/science.abk0297","url":"https://pubmed.ncbi.nlm.nih.gov/35511946/"}]}]}