{"publication_id":"7ed343e0-14c3-462a-90d6-3d35697861d8","content_hash":"sha256:d30eda08f917975b6d91998f7f3a1d50b073b9ceedb73086a16d2edb9b9f8a83","nodes":[{"id":"7ed343e0-14c3-462a-90d6-3d35697861d8","type":"publication","title":"telomere: source literature clusters around skin, not broad aging endpoints"},{"id":"claim_1","type":"claim","text":"Unsupported use: claiming lifespan extension, clinical benefit, or intervention efficacy from this bundle."},{"id":"claim_2","type":"claim","text":"Context only, not claim-expanding: Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. DOI `10.1126/science.aab3389`"},{"id":"claim_3","type":"claim","text":"Direct endpoint evidence showing the boundary is incidental rather than central to telomere."},{"id":"source_1","type":"source","study":"Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies","year":2025,"doi":"10.3389/fphar.2025.1592596","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection","year":2015,"doi":"10.1126/science.aab3389","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Endocrine Controls of Skin Aging","year":2025,"doi":"10.1210/endrev/bnae034","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Decoding Skin Aging: A Review of Mechanisms, Markers, and Modern Therapies","year":2025,"doi":"10.3390/cosmetics12040144","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_5","type":"source","study":"Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly","year":2017,"doi":"10.1182/blood-2017-02-769869","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"7ed343e0-14c3-462a-90d6-3d35697861d8","to":"claim_1","type":"contains_claim"},{"from":"7ed343e0-14c3-462a-90d6-3d35697861d8","to":"claim_2","type":"contains_claim"},{"from":"7ed343e0-14c3-462a-90d6-3d35697861d8","to":"claim_3","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}