{"publication_id":"798fcdb7-5e51-43e8-978e-937dfca0ad1c","traces":[{"claim_id":"claim_1","claim":"Evidence-honesty note: 24/36 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_2","claim":"This synthesis tests the thesis that evidence for Calcium Supplementation Effects is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_3","claim":"Calcium supplementation has long been proposed as a low-cost public-health lever for bone, cardiovascular, and pregnancy-related outcomes, yet contemporary evidence has been complicated by discrepant findings across indications, populations, and dosing regimens.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_4","claim":"We conducted an AI-assisted structured evidence synthesis across the curated source set, applying a transparent audit trail in which each study was tagged for design, directness, outcome class, and direction of effect before integration.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_5","claim":"Across the corpus, the evidence base is context-dependent rather than uniformly favorable: pre-eclampsia prevention, certain insulin-related endpoints, and selected bone-fracture outcomes show benefit, while older-adult and pregnancy inflammation biomarkers, recurrent cardiovascular events, and several body-composition endpoints remain null or unfavorable, with mechanistic plausibility (Ioannidis 2005) coexisting alongside sparse or mixed human-RCT confirmation.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_6","claim":"We conclude that calcium supplementation should not be framed as a monolithic intervention: the most defensible indications remain high-risk pregnancy, while bone-fracture benefit in community-dwelling older adults and cardiovascular safety in at-risk populations remain insufficiently resolved and warrant further direct, outcome-stratified randomized evaluation.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_7","claim":"Evidence-abstraction note.** The 36 retained reference papers are not 36 independent primary clinical trials: 24 are review, indirect, mechanistic, or registered-protocol source-level summaries, and 12 are classified as direct interventional evidence. Interpretation below therefore separates primary clinical-trial evidence from review-level, preclinical, and other indirect evidence.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_8","claim":"This manuscript is reported as a Thin-corpus evidence brief. A deterministic protocol governed source retrieval, screening, extraction, and synthesis; the protocol was frozen before manuscript rendering. The full audit trail is in the supplementary `methods_pack.json` and the timestamped submission directory `synthesis-calcium_supplementation_effects-v06-DAILY-2026-07-01T12-45-35Z-R2`.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_9","claim":"The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_10","claim":"Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_11","claim":"Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, contextual adjacent evidence, dosing and pharmacokinetics, immune and inflammation, longevity, muscle function, skeletal, fracture, and bone); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_12","claim":"Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.","candidate_sources":[{"source_id":"source_1","study":"Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial","doi":"10.1136/bmjopen-2021-060189","url":"https://doi.org/10.1136/bmjopen-2021-060189","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis","doi":"10.1111/nyas.14729","url":"https://doi.org/10.1111/nyas.14729","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial","doi":"10.1177/0379572120944671","url":"https://doi.org/10.1177/0379572120944671","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis","doi":"10.1007/s10654-020-00710-8","url":"https://doi.org/10.1007/s10654-020-00710-8","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_5","study":"The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials","doi":"10.7554/eLife.79002","url":"https://doi.org/10.7554/eLife.79002","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"}]},{"claim_id":"claim_13","claim":"Additional corpus sources included animal/preclinical evidence; 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