{"publication_id":"64624378-99b2-4428-8eb3-b291c8a1215f","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials","doi":"10.1186/s12906-021-03381-4","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases","doi":"10.21873/invivo.14235","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial","doi":"10.1002/jbmr.4115","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail","doi":"10.1186/s12903-023-02877-4","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis","doi":"10.3389/fendo.2024.1463027","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy","doi":"10.3390/molecules25235645","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Comparison of Resveratrol Supplementation and Energy Restriction Effects on Sympathetic Nervous System Activity and Vascular Reactivity: A Randomized Clinical Trial","doi":"10.3390/molecules26113168","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Effect of resveratrol supplementation on hepatic steatosis and cardiovascular indices in overweight subjects with type 2 diabetes: a double-blind, randomized controlled trial","doi":"10.1186/s12872-022-02637-2","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial.","doi":"10.1080/1028415x.2024.2425649","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Trans -Resveratrol Supplementation and Endothelial Function during the Fasting and Postprandial Phase: A Randomized Placebo-Controlled Trial in Overweight and Slightly Obese Participants","doi":"10.3390/nu9060596","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.","doi":"10.1039/c8fo01259h","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"The effects of resveratrol supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.","doi":"10.1017/s0007114515002433","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"Ioannidis 2005","doi":"10.1371/journal.pmed.0020124","risk_of_bias":"not appraised in public sidecar","directness":"citation"}]}