{"publication_id":"62637e62-c4f7-4093-85a4-d608a73edbf5","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity.","doi":"10.7759/cureus.98514","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice","doi":"10.7554/eLife.16351","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer","doi":"10.1111/acel.12496","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction","doi":"10.1111/acel.12194","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice","doi":"10.1038/nature08221","risk_of_bias":"not appraised in public sidecar","directness":"primary"}]}