{"publication_id":"5656b611-9e22-4b55-bce0-289625f554db","content_hash":"sha256:224501ae3c455f85c88d8e0673cae79fd3783c7c7a7e5f0fad677d6de5c1ff8d","nodes":[{"id":"5656b611-9e22-4b55-bce0-289625f554db","type":"publication","title":"telomere: one bounded, context-dependent signal across receipts"},{"id":"claim_1","type":"claim","text":"Across retrieved fact-level receipts for telomere, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?"},{"id":"claim_2","type":"claim","text":"Finding: The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL"},{"id":"claim_3","type":"claim","text":"Intervention/exposure: genetically determined longer telomere length (per 250 base pairs increase)"},{"id":"claim_4","type":"claim","text":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies [review; 2017] doi:10.1158/1055-9965.epi-16-0968"},{"id":"claim_5","type":"claim","text":"Finding: In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]."},{"id":"claim_6","type":"claim","text":"Finding: longer telomeres were associated with better scores on DSST (β=0.051 per s.d.-increase of TL; 95% CI: 0.024, 0.077; P=0.0002)"},{"id":"claim_7","type":"claim","text":"This receipt-backed scoping note has one bounded signal: telomere shows context-dependent, not uniformly convergent associations across this 5-source primary/review bundle (2017-2023). Grouped by direction, directionally favorable: 1 receipt(s) | other/mixed: 4 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. Concrete source-level examples: This revealed a significant effect of treatment on telomere dynamics (d=0.36); The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL; but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16)."},{"id":"claim_8","type":"claim","text":"null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable."},{"id":"claim_9","type":"claim","text":"other/mixed: Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population — The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL"},{"id":"claim_10","type":"claim","text":"other/mixed: Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16)"},{"id":"claim_11","type":"claim","text":"other/mixed: The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]."},{"id":"claim_12","type":"claim","text":"directionally favorable: Short telomere length is associated with impaired cognitive performance in European ancestry cohorts — longer telomeres were associated with better scores on DSST (β=0.051 per s.d.-increase of TL; 95% CI: 0.024, 0.077; P=0.0002)"},{"id":"claim_13","type":"claim","text":"Specific moderators in this bundle are population/indication (13,894 cases and 71,672 controls from 28 studies in 25 articles; European ancestry cohorts (N=17,052; mean age=59.2±8.8 years); UK Biobank participants aged 60 and older; interventional studies manipulating oxidative stress; liver disease cohort), study design/evidence type (primary/review). Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable."},{"id":"claim_14","type":"claim","text":"The selected receipts group because each carries a fact-level extraction for telomere; they separate by context (human clinical/observational and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim."},{"id":"claim_15","type":"claim","text":"The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate."},{"id":"source_1","type":"source","study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","year":2023,"doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","year":2021,"doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","year":2019,"doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","year":2017,"doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_5","type":"source","study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","year":2017,"doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_1","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_2","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_3","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_4","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_5","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_6","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_7","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_8","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_9","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_10","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_11","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_12","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_13","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_14","type":"contains_claim"},{"from":"5656b611-9e22-4b55-bce0-289625f554db","to":"claim_15","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}