{"publication_id":"5656b611-9e22-4b55-bce0-289625f554db","traces":[{"claim_id":"claim_1","claim":"Across retrieved fact-level receipts for telomere, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_2","claim":"Finding: The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_3","claim":"Intervention/exposure: genetically determined longer telomere length (per 250 base pairs increase)","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_4","claim":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies [review; 2017] doi:10.1158/1055-9965.epi-16-0968","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_5","claim":"Finding: In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238].","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_6","claim":"Finding: longer telomeres were associated with better scores on DSST (β=0.051 per s.d.-increase of TL; 95% CI: 0.024, 0.077; P=0.0002)","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_7","claim":"This receipt-backed scoping note has one bounded signal: telomere shows context-dependent, not uniformly convergent associations across this 5-source primary/review bundle (2017-2023). Grouped by direction, directionally favorable: 1 receipt(s) | other/mixed: 4 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. Concrete source-level examples: This revealed a significant effect of treatment on telomere dynamics (d=0.36); The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL; but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16).","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_8","claim":"null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_9","claim":"other/mixed: Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population — The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_10","claim":"other/mixed: Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16)","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_11","claim":"other/mixed: The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238].","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_12","claim":"directionally favorable: Short telomere length is associated with impaired cognitive performance in European ancestry cohorts — longer telomeres were associated with better scores on DSST (β=0.051 per s.d.-increase of TL; 95% CI: 0.024, 0.077; P=0.0002)","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_13","claim":"Specific moderators in this bundle are population/indication (13,894 cases and 71,672 controls from 28 studies in 25 articles; European ancestry cohorts (N=17,052; mean age=59.2±8.8 years); UK Biobank participants aged 60 and older; interventional studies manipulating oxidative stress; liver disease cohort), study design/evidence type (primary/review). Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable.","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_14","claim":"The selected receipts group because each carries a fact-level extraction for telomere; they separate by context (human clinical/observational and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]},{"claim_id":"claim_15","claim":"The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.","candidate_sources":[{"study":"Does oxidative stress shorten telomeres in vivo? A meta-analysis","doi":"10.1016/j.arr.2023.101854","url":"https://doi.org/10.1016/j.arr.2023.101854"},{"study":"Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population","doi":"10.1002/hep4.1803","url":"https://doi.org/10.1002/hep4.1803"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":"https://doi.org/10.1111/acel.13017"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":"https://doi.org/10.1158/1055-9965.epi-16-0968"},{"study":"Short telomere length is associated with impaired cognitive performance in European ancestry cohorts","doi":"10.1038/tp.2017.73","url":"https://doi.org/10.1038/tp.2017.73"}]}]}