{"publication_id":"55da1db9-6ae1-4b52-ab80-ab62f546525d","content_hash":"sha256:dac60fbfde059b150c4a7e3dffafe907e072fb6b588db9e48003b876bfb7a13d","nodes":[{"id":"55da1db9-6ae1-4b52-ab80-ab62f546525d","type":"publication","title":"vitamin D supplementation: one bounded, context-dependent signal across receipts"},{"id":"claim_1","type":"claim","text":"Across retrieved fact-level receipts for vitamin D supplementation, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?"},{"id":"claim_2","type":"claim","text":"Finding: significant decrease in advanced oxidation protein products levels over the 3-month period when higher vitamin D doses are given"},{"id":"claim_3","type":"claim","text":"This receipt-backed scoping note has one bounded signal: vitamin D supplementation shows context-dependent, not uniformly convergent associations across this 5-source primary/review bundle (2018-2023). Grouped by direction, directionally favorable: 2 receipt(s) | other/mixed: 3 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: whey protein supplementation significantly improved appendicular lean mass and physical function (SMD = 1.211; 95% CI: 0.588, 1.834; n = 16); significant decrease in advanced oxidation protein products levels over the 3-month period when higher vitamin D doses are given; at first restaging, 32.0 ng/mL vs 18.7 ng/mL (difference, 12.8 ng/mL [95% CI, 9.0 to 16.6], P < .001)."},{"id":"claim_4","type":"claim","text":"other/mixed: The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study — significant decrease in advanced oxidation protein products levels over the 3-month period when higher vitamin D doses are given"},{"id":"claim_5","type":"claim","text":"Specific moderators in this bundle are population/indication (Patients with type 2 diabetes on standard metformin therapy; Type 2 diabetes patients; Vitamin D deficient elderly persons (serum 25-(OH)D <30 ng/mL); patients with advanced or metastatic colorectal cancer; sarcopenic/frail older adults), study design/evidence type (primary/review). Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable."},{"id":"claim_6","type":"claim","text":"The selected receipts group because each carries a fact-level extraction for vitamin D supplementation; they separate by context (human clinical/observational and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim."},{"id":"claim_7","type":"claim","text":"The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate."},{"id":"source_1","type":"source","study":"Whey Protein Supplementation with or without Vitamin D on Sarcopenia-Related Measures: A Systematic Review and Meta-Analysis","year":2023,"doi":"10.1016/j.advnut.2023.05.011","url":"https://doi.org/10.1016/j.advnut.2023.05.011","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study","year":2021,"doi":"10.3389/fendo.2021.610893","url":"https://doi.org/10.3389/fendo.2021.610893","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Effect of High-Dose vs Standard-Dose Vitamin D<sub>3</sub> Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer","year":2019,"doi":"10.1001/jama.2019.2402","url":"https://doi.org/10.1001/jama.2019.2402","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial","year":2019,"doi":"10.3389/fimmu.2019.00065","url":"https://doi.org/10.3389/fimmu.2019.00065","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis","year":2018,"doi":"10.3390/nu10030375","url":"https://doi.org/10.3390/nu10030375","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"}],"edges":[{"from":"55da1db9-6ae1-4b52-ab80-ab62f546525d","to":"claim_1","type":"contains_claim"},{"from":"55da1db9-6ae1-4b52-ab80-ab62f546525d","to":"claim_2","type":"contains_claim"},{"from":"55da1db9-6ae1-4b52-ab80-ab62f546525d","to":"claim_3","type":"contains_claim"},{"from":"55da1db9-6ae1-4b52-ab80-ab62f546525d","to":"claim_4","type":"contains_claim"},{"from":"55da1db9-6ae1-4b52-ab80-ab62f546525d","to":"claim_5","type":"contains_claim"},{"from":"55da1db9-6ae1-4b52-ab80-ab62f546525d","to":"claim_6","type":"contains_claim"},{"from":"55da1db9-6ae1-4b52-ab80-ab62f546525d","to":"claim_7","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}