{"publication_id":"556ed33d-b232-4c19-a24c-849a8c2d81a6","content_hash":"sha256:392418f67bcf7a361ea209bbbae63831f67fa217fbb99f663f8f0ce1a9f7c420","nodes":[{"id":"556ed33d-b232-4c19-a24c-849a8c2d81a6","type":"publication","title":"The Omega-6/Omega-3 Ratio as a Mortality Biomarker: Bridging Observational Data and Interventional Null Results"},{"id":"claim_1","type":"claim","text":"The direct receipts support a narrow working claim: Supplementation was associated with reduced risk of MI (relative risk [RR], 0.87; 95% CI, 0.80 to 0.96), high certainty NNT of 272; but not CVD events (RR, 0.95; 95% CI, 0.90 to 1.00). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"Real tension: the useful signal is narrower than the topic label. The lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction."},{"id":"claim_4","type":"claim","text":"`fact_id=140174` (`A_core`) — Supplementation was associated with reduced risk of MI (relative risk [RR], 0.87; 95% CI, 0.80 to 0.96), high certainty NNT of 272 doi=10.1016/j.mayocp.2020.08.034"},{"id":"claim_5","type":"claim","text":"`fact_id=1138` (`A_core`) — little or no effect of increasing LCn3 on all-cause mortality (risk ratio (RR) 0.97, 95% CI 0.93 to 1.01 doi=10.1002/14651858.cd003177.pub5"},{"id":"claim_6","type":"claim","text":"`fact_id=178493` (`A_core`) — the 3 treatments combined showed a significant 39% decreased odds of becoming prefrail compared to the control doi=10.1093/gerona/glad073"},{"id":"claim_7","type":"claim","text":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"},{"id":"claim_8","type":"claim","text":"`fact_id=1138` (`A_core`) — little or no effect of increasing LCn3 on all-cause mortality (risk ratio (RR) 0.97, 95% CI 0.93 to 1.01 Source: Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease"},{"id":"source_1","type":"source","study":"Effect of Omega-3 Dosage on Cardiovascular Outcomes","year":2020,"doi":"10.1016/j.mayocp.2020.08.034","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Effects of Omega-3 Polyunsaturated Fatty Acids on Brain Functions: A Systematic Review","year":2022,"doi":"10.7759/cureus.30091","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: A population-based cohort study in UK Biobank","year":2024,"doi":"10.7554/elife.90132.3","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease","year":2020,"doi":"10.1002/14651858.cd003177.pub5","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"The Effects of Vitamin D Supplementation on Musculoskeletal Health: The VITAL and DO-Health Trials","year":2023,"doi":"10.1093/gerona/glad073","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_6","type":"source","study":"Omega-3 Fatty Acids and Cardiovascular Disease: Are There Benefits?","year":2016,"doi":"10.1007/s11936-016-0487-1","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_7","type":"source","study":"Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance among the Elderly: A Meta-Analysis","year":2020,"doi":"10.3390/nu12123739","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"}],"edges":[{"from":"556ed33d-b232-4c19-a24c-849a8c2d81a6","to":"claim_1","type":"contains_claim"},{"from":"556ed33d-b232-4c19-a24c-849a8c2d81a6","to":"claim_2","type":"contains_claim"},{"from":"556ed33d-b232-4c19-a24c-849a8c2d81a6","to":"claim_3","type":"contains_claim"},{"from":"556ed33d-b232-4c19-a24c-849a8c2d81a6","to":"claim_4","type":"contains_claim"},{"from":"556ed33d-b232-4c19-a24c-849a8c2d81a6","to":"claim_5","type":"contains_claim"},{"from":"556ed33d-b232-4c19-a24c-849a8c2d81a6","to":"claim_6","type":"contains_claim"},{"from":"556ed33d-b232-4c19-a24c-849a8c2d81a6","to":"claim_7","type":"contains_claim"},{"from":"556ed33d-b232-4c19-a24c-849a8c2d81a6","to":"claim_8","type":"contains_claim"}],"screening":{"identified":7,"screened":7,"excluded":0,"included":7,"included_or_retained":7,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"7 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}