{"publication_id":"55517e8f-0869-4695-bf27-5ef15eac8e31","content_hash":"sha256:80580c92e9c8e34837c513669ce12a8651be54122e9de6fcca7219fa27481caa","nodes":[{"id":"55517e8f-0869-4695-bf27-5ef15eac8e31","type":"publication","title":"Risk factors across may hinge on a boundary condition"},{"id":"claim_1","type":"claim","text":"approximately 40% of dementia cases worldwide could be attributable to 12 modifiable risk factors. Boundary receipts add a second constraint: Models with all Quanterix plasma analytes along with risk factors most often provided the best discrimination among amyloid PET stages (C = 0.78-0.82)."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"The interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition."},{"id":"claim_4","type":"claim","text":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?"},{"id":"claim_5","type":"claim","text":"`fact_id=142261` (`A_core`) — approximately 40% of dementia cases worldwide could be attributable to 12 modifiable risk factors doi=10.1111/joim.13227"},{"id":"claim_6","type":"claim","text":"`fact_id=170989` (`A_core`) — Globally, 61·0% (59·6–62·4) of deaths were attributed to the GBD 2017 risk factors. doi=10.1016/s0140-6736(19)31429-1"},{"id":"claim_7","type":"claim","text":"`fact_id=177576` (`A_core`) — up to 90% of strokes might be prevented by addressing and treating ten modifiable stroke risk factors, half of which are related to lifestyle modifications. doi=10.3390/medicina60030504"},{"id":"claim_8","type":"claim","text":"`fact_id=93195` (`A_core`) — 45.1% of cancer deaths (265,150 of 587,521 deaths) were attributable to evaluated risk factors. doi=10.3322/caac.21440"},{"id":"claim_9","type":"claim","text":"`fact_id=93194` (`A_core`) — an estimated 42.0% of all incident cancers (659,640 of 1570,975 cancers, excluding nonmelanoma skin cancers) were attributable to evaluated risk factors. doi=10.3322/caac.21440"},{"id":"claim_10","type":"claim","text":"`fact_id=98930` (`A_core`) — Prevalence of SCD increased from 3.9% among adults with no risk factors to 25.0% among those with four or more risk factors. doi=10.15585/mmwr.mm7120a2"},{"id":"claim_11","type":"claim","text":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"},{"id":"claim_12","type":"claim","text":"`fact_id=143088` (`B_context`) — Models with all Quanterix plasma analytes along with risk factors most often provided the best discrimination among amyloid PET stages (C = 0.78-0.82) doi=10.1093/brain/awad042"},{"id":"claim_13","type":"claim","text":"`fact_id=143092` (`B_context`) — Lilly p-tau217 did not improve over a model with all Quanterix plasma analytes and risk factors (C = 0.85 versus 0.83) doi=10.1093/brain/awad042"},{"id":"claim_14","type":"claim","text":"`fact_id=143092` (`B_context`) — Lilly p-tau217 did not improve over a model with all Quanterix plasma analytes and risk factors (C = 0.85 versus 0.83) Source: Predicting amyloid PET and tau PET stages with plasma biomarkers"},{"id":"source_1","type":"source","study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","year":2020,"doi":"10.1111/joim.13227","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","year":2019,"doi":"10.1016/s0140-6736(19)31429-1","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","year":2024,"doi":"10.3390/medicina60030504","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_4","type":"source","study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","year":2017,"doi":"10.3322/caac.21440","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","year":2022,"doi":"10.15585/mmwr.mm7120a2","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_6","type":"source","study":"Predicting amyloid PET and tau PET stages with plasma biomarkers","year":2023,"doi":"10.1093/brain/awad042","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_1","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_2","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_3","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_4","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_5","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_6","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_7","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_8","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_9","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_10","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_11","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_12","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_13","type":"contains_claim"},{"from":"55517e8f-0869-4695-bf27-5ef15eac8e31","to":"claim_14","type":"contains_claim"}],"screening":{"identified":6,"screened":6,"excluded":0,"included":6,"included_or_retained":6,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"6 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}