{"publication_id":"55517e8f-0869-4695-bf27-5ef15eac8e31","traces":[{"claim_id":"claim_1","claim":"approximately 40% of dementia cases worldwide could be attributable to 12 modifiable risk factors. Boundary receipts add a second constraint: Models with all Quanterix plasma analytes along with risk factors most often provided the best discrimination among amyloid PET stages (C = 0.78-0.82).","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_2","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_3","claim":"The interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition.","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_4","claim":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_5","claim":"`fact_id=142261` (`A_core`) — approximately 40% of dementia cases worldwide could be attributable to 12 modifiable risk factors doi=10.1111/joim.13227","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_6","claim":"`fact_id=170989` (`A_core`) — Globally, 61·0% (59·6–62·4) of deaths were attributed to the GBD 2017 risk factors. doi=10.1016/s0140-6736(19)31429-1","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_7","claim":"`fact_id=177576` (`A_core`) — up to 90% of strokes might be prevented by addressing and treating ten modifiable stroke risk factors, half of which are related to lifestyle modifications. doi=10.3390/medicina60030504","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_8","claim":"`fact_id=93195` (`A_core`) — 45.1% of cancer deaths (265,150 of 587,521 deaths) were attributable to evaluated risk factors. doi=10.3322/caac.21440","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_9","claim":"`fact_id=93194` (`A_core`) — an estimated 42.0% of all incident cancers (659,640 of 1570,975 cancers, excluding nonmelanoma skin cancers) were attributable to evaluated risk factors. doi=10.3322/caac.21440","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_10","claim":"`fact_id=98930` (`A_core`) — Prevalence of SCD increased from 3.9% among adults with no risk factors to 25.0% among those with four or more risk factors. doi=10.15585/mmwr.mm7120a2","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_11","claim":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_12","claim":"`fact_id=143088` (`B_context`) — Models with all Quanterix plasma analytes along with risk factors most often provided the best discrimination among amyloid PET stages (C = 0.78-0.82) doi=10.1093/brain/awad042","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_13","claim":"`fact_id=143092` (`B_context`) — Lilly p-tau217 did not improve over a model with all Quanterix plasma analytes and risk factors (C = 0.85 versus 0.83) doi=10.1093/brain/awad042","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]},{"claim_id":"claim_14","claim":"`fact_id=143092` (`B_context`) — Lilly p-tau217 did not improve over a model with all Quanterix plasma analytes and risk factors (C = 0.85 versus 0.83) Source: Predicting amyloid PET and tau PET stages with plasma biomarkers","candidate_sources":[{"study":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","doi":"10.1111/joim.13227","url":null},{"study":"Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))","doi":"10.1016/s0140-6736(19)31429-1","url":null},{"study":"Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review","doi":"10.3390/medicina60030504","url":null},{"study":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States","doi":"10.3322/caac.21440","url":null},{"study":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019","doi":"10.15585/mmwr.mm7120a2","url":null}]}]}