{"publication_id":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","traces":[{"claim_id":"claim_1","claim":"Across retrieved fact-level receipts for mtor, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_2","claim":"Finding: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_3","claim":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. [primary; 2013] doi:10.1016/j.celrep.2013.07.030","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_4","claim":"Finding: Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_5","claim":"This receipt-backed scoping note has one bounded signal: mtor shows context-dependent, not convergent, associations across this 5-source primary/review bundle (2010-2024). Grouped by direction, directionally favorable: RAD001 improved influenza vaccine response by ~20% in the elderly; Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition... | other/mixed: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P =...; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10; RAD001 improved influenza vaccine response by ~20% in the elderly; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%).","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_6","claim":"other/mixed: International consensus on post-transplantation diabetes mellitus — observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_7","claim":"other/mixed: Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. — exhibit an approximately 20% increase in median survival.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_8","claim":"directionally favorable: Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis — Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_9","claim":"Candidate moderators are population or indication, endpoint, comparator, and study design/evidence type; these dimensions explain why the receipts should be read as divergent evidence fronts, not one pooled effect.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_10","claim":"The selected receipts group because each carries a fact-level extraction for mtor; they separate by context (animal model, human clinical/observational, and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_11","claim":"Source-literature boundary for mtor: the listed sources define separate evidence fronts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_12","claim":"The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]}]}