{"publication_id":"40ce88b3-5626-4801-9327-2ac3ebe3f796","content_hash":"sha256:d8b3b2e94f65c4a6bcdf78c9e6e758a2eb9eccc910db47c632b77ae1a2361a45","nodes":[{"id":"40ce88b3-5626-4801-9327-2ac3ebe3f796","type":"publication","title":"Bounded Klotho signal: the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29-13.48)"},{"id":"claim_1","type":"claim","text":"The direct receipts support a narrow working claim: the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29-13.48); HR for tertile three of Klotho was 2.18 (95% CI 0.91-2.23). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"Real tension: the useful signal is narrower than the topic label. The lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction."},{"id":"claim_4","type":"claim","text":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?"},{"id":"claim_5","type":"claim","text":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"},{"id":"claim_6","type":"claim","text":"`fact_id=187886` (`B_context`) — Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge' g [95%CI] 1.3 [0.69-1.90]; P < 0.0001) doi=10.1038/s41598-022-22123-1"},{"id":"claim_7","type":"claim","text":"_Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._"},{"id":"source_1","type":"source","study":"Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients","year":2015,"doi":"10.1155/2015/406269","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.","year":2014,"doi":"10.1371/journal.pone.0100688","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.","year":2013,"doi":"10.5414/cn107800","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis","year":2019,"doi":"10.1186/s12882-019-1391-1","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.","year":2013,"doi":"10.1097/shk.0b013e3182845445","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"40ce88b3-5626-4801-9327-2ac3ebe3f796","to":"claim_1","type":"contains_claim"},{"from":"40ce88b3-5626-4801-9327-2ac3ebe3f796","to":"claim_2","type":"contains_claim"},{"from":"40ce88b3-5626-4801-9327-2ac3ebe3f796","to":"claim_3","type":"contains_claim"},{"from":"40ce88b3-5626-4801-9327-2ac3ebe3f796","to":"claim_4","type":"contains_claim"},{"from":"40ce88b3-5626-4801-9327-2ac3ebe3f796","to":"claim_5","type":"contains_claim"},{"from":"40ce88b3-5626-4801-9327-2ac3ebe3f796","to":"claim_6","type":"contains_claim"},{"from":"40ce88b3-5626-4801-9327-2ac3ebe3f796","to":"claim_7","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}