{"publication_id":"40ce88b3-5626-4801-9327-2ac3ebe3f796","traces":[{"claim_id":"claim_1","claim":"The direct receipts support a narrow working claim: the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29-13.48); HR for tertile three of Klotho was 2.18 (95% CI 0.91-2.23). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim.","candidate_sources":[{"study":"Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients","doi":"10.1155/2015/406269","url":null},{"study":"Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.","doi":"10.1371/journal.pone.0100688","url":null},{"study":"The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.","doi":"10.5414/cn107800","url":null},{"study":"Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis","doi":"10.1186/s12882-019-1391-1","url":null},{"study":"Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.","doi":"10.1097/shk.0b013e3182845445","url":null}]},{"claim_id":"claim_2","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.","candidate_sources":[{"study":"Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients","doi":"10.1155/2015/406269","url":null},{"study":"Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.","doi":"10.1371/journal.pone.0100688","url":null},{"study":"The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.","doi":"10.5414/cn107800","url":null},{"study":"Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis","doi":"10.1186/s12882-019-1391-1","url":null},{"study":"Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.","doi":"10.1097/shk.0b013e3182845445","url":null}]},{"claim_id":"claim_3","claim":"Real tension: the useful signal is narrower than the topic label. The lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction.","candidate_sources":[{"study":"Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients","doi":"10.1155/2015/406269","url":null},{"study":"Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.","doi":"10.1371/journal.pone.0100688","url":null},{"study":"The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.","doi":"10.5414/cn107800","url":null},{"study":"Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis","doi":"10.1186/s12882-019-1391-1","url":null},{"study":"Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.","doi":"10.1097/shk.0b013e3182845445","url":null}]},{"claim_id":"claim_4","claim":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?","candidate_sources":[{"study":"Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients","doi":"10.1155/2015/406269","url":null},{"study":"Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.","doi":"10.1371/journal.pone.0100688","url":null},{"study":"The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.","doi":"10.5414/cn107800","url":null},{"study":"Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis","doi":"10.1186/s12882-019-1391-1","url":null},{"study":"Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.","doi":"10.1097/shk.0b013e3182845445","url":null}]},{"claim_id":"claim_5","claim":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._","candidate_sources":[{"study":"Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients","doi":"10.1155/2015/406269","url":null},{"study":"Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.","doi":"10.1371/journal.pone.0100688","url":null},{"study":"The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.","doi":"10.5414/cn107800","url":null},{"study":"Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis","doi":"10.1186/s12882-019-1391-1","url":null},{"study":"Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.","doi":"10.1097/shk.0b013e3182845445","url":null}]},{"claim_id":"claim_6","claim":"`fact_id=187886` (`B_context`) — Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge' g [95%CI] 1.3 [0.69-1.90]; P < 0.0001) doi=10.1038/s41598-022-22123-1","candidate_sources":[{"study":"Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients","doi":"10.1155/2015/406269","url":null},{"study":"Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.","doi":"10.1371/journal.pone.0100688","url":null},{"study":"The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.","doi":"10.5414/cn107800","url":null},{"study":"Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis","doi":"10.1186/s12882-019-1391-1","url":null},{"study":"Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.","doi":"10.1097/shk.0b013e3182845445","url":null}]},{"claim_id":"claim_7","claim":"_Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._","candidate_sources":[{"study":"Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients","doi":"10.1155/2015/406269","url":null},{"study":"Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.","doi":"10.1371/journal.pone.0100688","url":null},{"study":"The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.","doi":"10.5414/cn107800","url":null},{"study":"Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis","doi":"10.1186/s12882-019-1391-1","url":null},{"study":"Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.","doi":"10.1097/shk.0b013e3182845445","url":null}]}]}