{"publication_id":"3d1f5206-d783-478c-bff7-eac52c571f3c","content_hash":"sha256:c1238b05035f455c7f4d4af9010abb38c8150a8c65421d780e650c3c7d5adcce","nodes":[{"id":"3d1f5206-d783-478c-bff7-eac52c571f3c","type":"publication","title":"Memo: Metformin + Exercise — Protection Signal vs. Adaptation Deficit"},{"id":"claim_1","type":"claim","text":"Receipt 1 shows a pharmacologic adjunct (dapagliflozin) preserves training adaptations, while Receipt 2 reports a damage/injury-protection benefit that does not translate into improved performance, highlighting a split between protective and adaptive endpoints under the same metformin + exercise anchor."},{"id":"source_1","type":"source","study":"Influence of Sodium Glucose Cotransporter 2 Inhibition on Physiological Adaptation to Endurance Exercise Training.","year":2019,"doi":"10.1210/jc.2018-01741","url":"https://doi.org/10.1210/jc.2018-01741","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Metformin Protects Rat Skeletal Muscle from Physical Exercise-Induced Injury","year":2023,"doi":"10.3390/biomedicines11092334","url":"https://doi.org/10.3390/biomedicines11092334","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"3d1f5206-d783-478c-bff7-eac52c571f3c","to":"claim_1","type":"contains_claim"}],"screening":{"identified":2,"screened":2,"excluded":0,"included":2,"included_or_retained":2,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"2 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}