{"publication_id":"2371a466-c045-460d-a766-e242574bcc65","traces":[{"claim_id":"claim_1","claim":"Two 2024 randomized trials in older adults define the same dose/regime but land on different ledger sides. 10.1002/ptr.8171 is a systematic review of randomized clinical trials in older adults reporting that resveratrol combined with exercise improved exercise adaptation, muscle function, and physical performance/mobility. 10.1016/j.exger.2024.112479 is the embedded dose-ranging trial that explicitly set out to test resveratrol + exercise training on trimethylamine-N-oxide in older adults with high CVD risk and observed that TMAO concentration increased over time regardless of treatment arm (p = 0.04), with each dose producing distinct metabolite signatures.","candidate_sources":[{"source_id":"source_1","study":"Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise training among older adults.","doi":"10.1016/j.exger.2024.112479","url":"https://doi.org/10.1016/j.exger.2024.112479","support_kind":"direct_doi_match","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review.","doi":"10.1002/ptr.8171","url":"https://doi.org/10.1002/ptr.8171","support_kind":"direct_doi_match","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_2","claim":"10.1016/j.exger.2024.112479 — role=evidence; design=randomized_trial; population=human older adults with high CVD risk; outcome=dose/risk (TMAO and metabolite signatures); direction=negative/positive; support=direct/high.","candidate_sources":[{"source_id":"source_1","study":"Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise training among older adults.","doi":"10.1016/j.exger.2024.112479","url":"https://doi.org/10.1016/j.exger.2024.112479","support_kind":"direct_doi_match","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_3","claim":"10.1002/ptr.8171 — role=positive_signal; design=randomized_trial systematic review; population=human older adults; outcome=chronic/dose/long (muscle function, mobility, neuroprotection, cognition); direction=positive; support=direct/high.","candidate_sources":[{"source_id":"source_2","study":"Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review.","doi":"10.1002/ptr.8171","url":"https://doi.org/10.1002/ptr.8171","support_kind":"direct_doi_match","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_4","claim":"10.1249/MSS.0000000000000620 — role=mechanism; design=randomized_trial review; population=human; outcome=performance/risk/stress (ROS as adaptive signal); direction=negative/positive; support=direct/high.","candidate_sources":[{"source_id":"source_3","study":"Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.","doi":"10.1249/MSS.0000000000000620","url":"https://doi.org/10.1249/MSS.0000000000000620","support_kind":"direct_doi_match","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_5","claim":"10.1113/jphysiol.2013.266999 — role=boundary; design=randomized_trial commentary; population=human; outcome=damage/long/risk (vascular function); direction=negative; support=direct/high.","candidate_sources":[{"source_id":"source_4","study":"Attenuated effects of exercise with an antioxidant supplement: too much of a good thing?","doi":"10.1113/jphysiol.2013.266999","url":"https://doi.org/10.1113/jphysiol.2013.266999","support_kind":"direct_doi_match","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_6","claim":"Receipts describe trial and review-level safety reporting only; no clinical advice is inferred. The TMAO increase and the attenuated-exercise boundary are observed findings in the cited studies, not generalizable safety claims.","candidate_sources":[{"source_id":"source_1","study":"Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise training among older adults.","doi":"10.1016/j.exger.2024.112479","url":"https://doi.org/10.1016/j.exger.2024.112479","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review.","doi":"10.1002/ptr.8171","url":"https://doi.org/10.1002/ptr.8171","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_3","study":"Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.","doi":"10.1249/MSS.0000000000000620","url":"https://doi.org/10.1249/MSS.0000000000000620","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Attenuated effects of exercise with an antioxidant supplement: too much of a good thing?","doi":"10.1113/jphysiol.2013.266999","url":"https://doi.org/10.1113/jphysiol.2013.266999","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]}]}