{"publication_id":"21652f17-8a22-4863-aa37-ec5f4e1a7b90","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Clinical and economic outcomes of therapeutic plasma exchange and intravenous immunoglobulin for treating adults with autoimmune neurological disorders: a systematic review and meta-analysis","doi":"10.1186/s12883-026-04780-1","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study","doi":"10.1002/alz.12137","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Therapeutic Plasma Exchange in Myasthenia Gravis: A Systematic Literature Review and Meta-Analysis of Comparative Evidence","doi":"10.3389/fneur.2021.662856","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Neuropsychological, neuropsychiatric, and quality‐of‐life assessments in Alzheimer's disease patients treated with plasma exchange with albumin replacement from the randomized AMBAR study","doi":"10.1002/alz.12477","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Complications of Therapeutic Plasma Exchange in Pediatric Neuroimmune Disorders","doi":"10.3390/children12111457","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Pediatric Therapeutic Plasma Exchange: Characterization of Practice, Epidemiology, and Safety Profile at a Children's Hospital in the United States","doi":"10.1002/jca.70128","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"The Role of Therapeutic Plasma Exchange in the Management of Myeloma-Related Cast Nephropathy: A 10-Year Real-World Cohort Study","doi":"10.3390/jcm15020417","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange","doi":"10.1111/acel.70103","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Assessment of clinical characteristics, treatment responses, relapses, and survival in patients with thrombotic thrombocytopenic purpura undergoing therapeutic plasma exchange: A single-center experience","doi":"10.12669/pjms.42.4.14962","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Modulation of Cytokines and Immune Cells by Plasma Exchange in Patients With Certain Autoimmune Neurological Diseases","doi":"10.1002/iid3.70369","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Effect on haemostasis of different replacement fluids during therapeutic plasma exchange—A comparative multicentre observational study","doi":"10.1002/jca.22008","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Therapeutic plasma exchange in patients with sepsis: Secondary analysis of a cluster‐randomized controlled trial","doi":"10.1002/jca.22027","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial","doi":"10.1038/s41467-025-57198-7","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Severe autoimmune diffuse alveolar hemorrhage in children; early diagnosis and initiation of therapeutic plasma exchange may improve clinical outcomes","doi":"10.3389/fped.2026.1799535","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"“In-Series” Continuous Renal Replacement Therapy and Therapeutic Plasma Exchange: Single-Center Retrospective Cohort, 2018–2022","doi":"10.1097/PCC.0000000000003942","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Clinical Experience of Therapeutic Plasma Exchange (TPE) in Severe Leptospirosis: A Case Series from Sri Lanka","doi":"10.3390/tropicalmed11050132","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Pathogen‐reduced plasma, cryoprecipitate reduced for therapeutic plasma exchange","doi":"10.1111/trf.70099","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"What Is the Role of Therapeutic Plasma Exchange as an Adjunctive Treatment in Severe COVID-19: A Systematic Review","doi":"10.3390/v13081484","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Towards a clinical decision protocol for therapeutic plasma exchange based on biomarker patterns and machine learning","doi":"10.1186/s12911-026-03484-3","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Rescuing Cancer Immunity by Plasma Exchange in Metastatic Melanoma (ReCIPE-M1): protocol for a single-institution, open-label safety trial of plasma exchange to clear sPD-L1 for immunotherapy","doi":"10.1136/bmjopen-2021-050112","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Bleeding Risk Is Not Increased When Initiating Therapeutic Plasma Exchange in Adults Using Exclusively Albumin Replacement Fluid 2 Days After Percutaneous Kidney Biopsy","doi":"10.1002/jca.70122","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Successful Therapeutic Plasma Exchange Treatment After SARS‐CoV‐2 Infection—A Case Report","doi":"10.1002/ccr3.72725","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Neither Therapeutic Plasma Exchange nor High-Flux Hemodialysis Enhances the Removal of Chlorprothixene in Case of Intoxication despite a Drop in Plasma Levels: A Case Report","doi":"10.1159/000551514","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Clinical response of acute idiopathic polyradiculoneuritis treated with therapeutic plasma exchange in four dogs","doi":"10.1093/jvimsj/aalag090","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Case Report: Successful management of acute vincristine overdose in a cat with metastatic gastric lymphoma using therapeutic plasma exchange","doi":"10.3389/fvets.2026.1791728","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Separate (Asynchronous) Therapeutic Plasma Exchange (TPE) and Plasma Transfusion in the Patient with Severe TPE Complications: A Case Report","doi":"10.18502/ijhoscr.v19i1.17827","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Therapeutic plasma exchange for fibrinogen-associated hyperviscosity: results of the COVID-19 PLasma EXchange (COPLEX) randomized controlled trial.","doi":"10.1016/j.jtha.2024.12.021","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Reverse takotsubo cardiomyopathy in fulminant COVID-19 associated with cytokine release syndrome and resolution following therapeutic plasma exchange: a case-report","doi":"10.1186/s12872-020-01665-0","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"}]}