{"publication_id":"1ad636ff-4af7-42c3-9666-6fec14a4971c","content_hash":"sha256:9094d0afed377c6126d2849ce7ba92aad64f9e6a0bfb48e4b8503ce47cf55eff","nodes":[{"id":"1ad636ff-4af7-42c3-9666-6fec14a4971c","type":"publication","title":"Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A"},{"id":"claim_1","type":"claim","text":"10.1111/acel.13039 — role=evidence; design=randomized_trial; population=human; outcome=unspecified; direction=negative; support=direct/high; quote=\"placebo gained more lean body mass (p = .003) and thigh muscle mass (p < .001) than metformin … trend for blunted strength gai …\""},{"id":"claim_2","type":"claim","text":"10.1093/geroni/igy023.2009 — role=evidence; design=randomized_trial; population=human; outcome=unspecified; direction=positive; support=direct/high; quote=\"lean mass increased overall (P < 0.0001), with the metformin group gaining significantly less lean mass than the placebo group (P < 0.01) …\""},{"id":"claim_3","type":"claim","text":"10.3410/f.736671936.793569870 — role=replication; design=randomized_trial; population=human; outcome=unspecified; direction=negative; support=direct/high; quote=\"Faculty Opinions recommendation of Metformin blunts muscle hypertrophy in response to progressive resistance exercise training …\""},{"id":"claim_4","type":"claim","text":"Receipts describe feasibility-scale, randomized, double-blind, placebo-controlled trial evidence in adults aged 65+; no clinical advice is offered."},{"id":"source_1","type":"source","study":"Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial","year":2019,"doi":"10.1111/acel.13039","url":"https://doi.org/10.1111/acel.13039","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"METFORMIN TO AUGMENT STRENGTH TRAINING EFFECTIVE RESPONSE IN SENIORS: THE MASTERS TRIAL","year":2018,"doi":"10.1093/geroni/igy023.2009","url":"https://doi.org/10.1093/geroni/igy023.2009","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Faculty Opinions recommendation of Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial.","year":2020,"doi":"10.3410/f.736671936.793569870","url":"https://doi.org/10.3410/f.736671936.793569870","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"1ad636ff-4af7-42c3-9666-6fec14a4971c","to":"claim_1","type":"contains_claim"},{"from":"1ad636ff-4af7-42c3-9666-6fec14a4971c","to":"claim_2","type":"contains_claim"},{"from":"1ad636ff-4af7-42c3-9666-6fec14a4971c","to":"claim_3","type":"contains_claim"},{"from":"1ad636ff-4af7-42c3-9666-6fec14a4971c","to":"claim_4","type":"contains_claim"}],"screening":{"identified":3,"screened":3,"excluded":0,"included":3,"included_or_retained":3,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"3 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}