{"publication_id":"19dc964c-c04b-4c23-b723-e0397e5be483","content_hash":"sha256:aab877b0e1a9ba04878f2ca4ea27f8931192b29148f864b0962f1d5744991ce1","nodes":[{"id":"19dc964c-c04b-4c23-b723-e0397e5be483","type":"publication","title":"Alpha memo: metformin resistance training"},{"id":"claim_1","type":"claim","text":"Why this is surprising:** Receipt 1 establishes that metformin can interfere with resistance-training biology at the transcriptomic and hypertrophic level, yet Receipt 2 suggests the downstream glycaemic response to aerobic training survives metformin exposure — the same drug–exercise interaction thus appears molecularly disruptive but metabolically bounded."},{"id":"source_1","type":"source","study":"Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults","year":2020,"doi":"10.18632/aging.104096","url":"https://doi.org/10.18632/aging.104096","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Does metformin modify the effect on glycaemic control of aerobic exercise, resistance exercise or both?","year":2013,"doi":"10.1007/s00125-013-3026-6","url":"https://doi.org/10.1007/s00125-013-3026-6","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"19dc964c-c04b-4c23-b723-e0397e5be483","to":"claim_1","type":"contains_claim"}],"screening":{"identified":2,"screened":2,"excluded":0,"included":2,"included_or_retained":2,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"2 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}