{"publication_id":"124c3917-ffdc-4ae1-840c-cb71641cccd7","traces":[{"claim_id":"claim_1","claim":"Evidence-honesty note: 16/17 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_2","claim":"Evidence-boundary note: Because the retained corpus relies on absent or limited direct interventional hard-endpoint evidence and includes mixed, indirect, adjacent/mechanistic evidence, this synthesis is hypothesis-generating and not definitive. Null clinical findings and mechanistic plausibility are interpreted separately, so it does not support broad causal or policy claims; broad population-level proof is missing until direct human outcome studies replicate the signal with durable follow-up.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_3","claim":"This paper synthesizes evidence on Photobiomodulation across 17 accepted source papers and 433 high-confidence extracted claims.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_4","claim":"The evidence profile contains 1 direct clinical source, 12 adjacent clinical sources, and 4 mechanistic or model-system sources, with 16 cross-study disagreements across the evidence base.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_5","claim":"Positive study-level signals are summarized in the immune and inflammation outcome class, null signals in the contextual adjacent evidence, immune and inflammation outcome classes, and negative signals in no dominant outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_6","claim":"The conclusion is that Photobiomodulation remains a bounded geroscience case: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_7","claim":"Current evidence does not support clinical or policy use for geroprotection; the synthesis is evidentiary, not medical guidance.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_8","claim":"For Photobiomodulation, what does the retained evidence show about prognostic or risk-marker associations, causal or mechanistic evidence, treatment or intervention relevance, and the limits that direct, indirect, review-level, and mechanistic source designs impose on clinical actionability across outcome classes?","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_9","claim":"This manuscript is reported as a Thin-corpus evidence brief. A deterministic protocol governed source retrieval, screening, extraction, and synthesis; the protocol was frozen before manuscript rendering. The full audit trail is in the supplementary `methods_pack.json` and the timestamped submission directory `synthesis-photobiomodulation_red_light-v06-DAILY-2026-06-27T21-13-41Z`.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_10","claim":"The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_11","claim":"Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_12","claim":"Evidence-tension synthesis: claims grouped by outcome class (contextual adjacent evidence, immune and inflammation, mechanism, muscle function, safety and comorbidity); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_13","claim":"Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light 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extracted","directness":"primary"}]},{"claim_id":"claim_27","claim":"Quirk 2021: Effect of Red-to-Near Infrared Light and a Nitric Oxide Donor on the Oxygen Consumption of Isolated Cytochrome c Oxidase; 2 extracted claim(s); receipt-level direction is the coded finding; outcome=Contextual Adjacent Evidence; direction=null; directness=indirect; tier=B2.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_28","claim":"adjacent clinical-context evidence: Couturaud 2023, Nardi 2025, Huang 2025, Colombo 2021, Pelevin 2026, Quirk 2021","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_29","claim":"treatment or intervention-response evidence: Fan 2025, Phypers 2024, Merkle 2026, Mathioudaki 2023, Yang 2025, Soliman 2024","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_30","claim":"Synthesis interpretation: These source-level findings connect risk-marker, mechanistic, and intervention-adjacent signals into follow-up hypotheses, not a clinical efficacy claim. Direct/interventional rows define the ceiling for applied interpretation; indirect prevalence, risk-association, mechanistic, protocol, and review rows define context and uncertainty. Representative coded source verdicts remain: Anita 2025: outcome=Immune and Inflammation; direction=positive; directness=indirect; tier=B2; result=Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration; finding=representative statistic P < 0.01; source-level statistic reported; claims=81; Fan 2025: outcome=Contextual Adjacent Evidence; direction=unclear; directness=review; tier=B2; result=Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis; finding=representative statistic p < 0.00001; source-level statistic reported; claims=69; Nardi 2025: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2; result=Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity; finding=representative statistic p < 0.001; source-level statistic reported; claims=55; Huang 2025: outcome=Contextual Adjacent Evidence; direction=unclear; directness=direct; tier=A1; result=Red-light photobiomodulation improves cognition and neuropsychiatric symptoms in post-stroke cognitive impairment: a; finding=representative statistic P > 0.05; source-level statistic reported; claims=22. The bounded conclusion follows from source direction, outcome class, evidence tier, and directness rather than from source count alone. Publication-year note: citation years follow the manifest metadata; when DOI/PubMed dates differ, the source should be treated as bibliographic/in-press metadata and not used for year-specific claims.","candidate_sources":[{"source_id":"source_1","study":"Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration","doi":"10.1038/s41598-025-04873-w","url":"https://doi.org/10.1038/s41598-025-04873-w","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis","doi":"10.3389/fmed.2025.1640403","url":"https://doi.org/10.3389/fmed.2025.1640403","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"review-level"},{"source_id":"source_3","study":"Reverse skin aging signs by red light photobiomodulation","doi":"10.1111/srt.13391","url":"https://doi.org/10.1111/srt.13391","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity","doi":"10.3390/nu17213357","url":"https://doi.org/10.3390/nu17213357","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up","doi":"10.3390/jcm13237101","url":"https://doi.org/10.3390/jcm13237101","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]}]}