{"publication_id":"1217fcd5-4125-481d-a9d1-2778742fad95","content_hash":"sha256:38531a2650da8a77aae2137789176fba7cab9923f411ebdfb45caebe546701ca","nodes":[{"id":"1217fcd5-4125-481d-a9d1-2778742fad95","type":"publication","title":"Exercise longevity evidence is endpoint-specific, not a universal hard-outcome claim"},{"id":"claim_1","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; it should not be read as a general claim that exercise extends lifespan in every population."},{"id":"claim_2","type":"claim","text":"The practical anti-aging claim is narrower than the public-health slogan. The receipts support functional and cardiometabolic movement more directly than they support a clean hard-outcome longevity endpoint. That matters because longevity writers often collapse VO2, walking distance, blood pressure, glucose, complications, and mortality into one broad “exercise works” bucket."},{"id":"claim_3","type":"claim","text":"Preoperative exercise training in major-surgery adults increased peak oxygen uptake by +2 ml/kg/min (99% CI, 0.3 to 3.7) and was associated with fewer postoperative pulmonary complications (RR 0.52; 95% CI, 0.41 to 0.66). DOI `10.1513/annalsats.202002-183oc`."},{"id":"claim_4","type":"claim","text":"In older-vs-younger comparisons, exercise plus amino-acid nutrition did not erase age-related anabolic-resistance uncertainty; only 2 of 10 combined-intervention arms provided sufficient evidence. DOI `10.1152/ajpendo.00213.2016`."},{"id":"source_1","type":"source","study":"Preoperative Exercise Training to Prevent Postoperative Pulmonary Complications in Adults Undergoing Major Surgery. A Systematic Review and Meta-analysis with Trial Sequential Analysis","year":2020,"doi":"10.1513/annalsats.202002-183oc","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"Efficacy of Prehabilitation Including Exercise on Postoperative Outcomes Following Abdominal Cancer Surgery: A Systematic Review and Meta-Analysis","year":2021,"doi":"10.3389/fsurg.2021.628848","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Exercise-based cardiac rehabilitation for adults after heart valve surgery","year":2021,"doi":"10.1002/14651858.cd010876.pub3","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Exercise-based cardiac rehabilitation for coronary heart disease","year":2021,"doi":"10.1002/14651858.cd001800.pub4","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Does the muscle protein synthetic response to exercise and amino acid-based nutrition diminish with advancing age? A systematic review","year":2016,"doi":"10.1152/ajpendo.00213.2016","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"}],"edges":[{"from":"1217fcd5-4125-481d-a9d1-2778742fad95","to":"claim_1","type":"contains_claim"},{"from":"1217fcd5-4125-481d-a9d1-2778742fad95","to":"claim_2","type":"contains_claim"},{"from":"1217fcd5-4125-481d-a9d1-2778742fad95","to":"claim_3","type":"contains_claim"},{"from":"1217fcd5-4125-481d-a9d1-2778742fad95","to":"claim_4","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}