{"publication_id":"1217fcd5-4125-481d-a9d1-2778742fad95","traces":[{"claim_id":"claim_1","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; it should not be read as a general claim that exercise extends lifespan in every population.","candidate_sources":[{"study":"Preoperative Exercise Training to Prevent Postoperative Pulmonary Complications in Adults Undergoing Major Surgery. A Systematic Review and Meta-analysis with Trial Sequential Analysis","doi":"10.1513/annalsats.202002-183oc","url":null},{"study":"Efficacy of Prehabilitation Including Exercise on Postoperative Outcomes Following Abdominal Cancer Surgery: A Systematic Review and Meta-Analysis","doi":"10.3389/fsurg.2021.628848","url":null},{"study":"Exercise-based cardiac rehabilitation for adults after heart valve surgery","doi":"10.1002/14651858.cd010876.pub3","url":null},{"study":"Exercise-based cardiac rehabilitation for coronary heart disease","doi":"10.1002/14651858.cd001800.pub4","url":null},{"study":"Does the muscle protein synthetic response to exercise and amino acid-based nutrition diminish with advancing age? A systematic review","doi":"10.1152/ajpendo.00213.2016","url":null}]},{"claim_id":"claim_2","claim":"The practical anti-aging claim is narrower than the public-health slogan. The receipts support functional and cardiometabolic movement more directly than they support a clean hard-outcome longevity endpoint. That matters because longevity writers often collapse VO2, walking distance, blood pressure, glucose, complications, and mortality into one broad “exercise works” bucket.","candidate_sources":[{"study":"Preoperative Exercise Training to Prevent Postoperative Pulmonary Complications in Adults Undergoing Major Surgery. A Systematic Review and Meta-analysis with Trial Sequential Analysis","doi":"10.1513/annalsats.202002-183oc","url":null},{"study":"Efficacy of Prehabilitation Including Exercise on Postoperative Outcomes Following Abdominal Cancer Surgery: A Systematic Review and Meta-Analysis","doi":"10.3389/fsurg.2021.628848","url":null},{"study":"Exercise-based cardiac rehabilitation for adults after heart valve surgery","doi":"10.1002/14651858.cd010876.pub3","url":null},{"study":"Exercise-based cardiac rehabilitation for coronary heart disease","doi":"10.1002/14651858.cd001800.pub4","url":null},{"study":"Does the muscle protein synthetic response to exercise and amino acid-based nutrition diminish with advancing age? A systematic review","doi":"10.1152/ajpendo.00213.2016","url":null}]},{"claim_id":"claim_3","claim":"Preoperative exercise training in major-surgery adults increased peak oxygen uptake by +2 ml/kg/min (99% CI, 0.3 to 3.7) and was associated with fewer postoperative pulmonary complications (RR 0.52; 95% CI, 0.41 to 0.66). DOI `10.1513/annalsats.202002-183oc`.","candidate_sources":[{"study":"Preoperative Exercise Training to Prevent Postoperative Pulmonary Complications in Adults Undergoing Major Surgery. A Systematic Review and Meta-analysis with Trial Sequential Analysis","doi":"10.1513/annalsats.202002-183oc","url":null},{"study":"Efficacy of Prehabilitation Including Exercise on Postoperative Outcomes Following Abdominal Cancer Surgery: A Systematic Review and Meta-Analysis","doi":"10.3389/fsurg.2021.628848","url":null},{"study":"Exercise-based cardiac rehabilitation for adults after heart valve surgery","doi":"10.1002/14651858.cd010876.pub3","url":null},{"study":"Exercise-based cardiac rehabilitation for coronary heart disease","doi":"10.1002/14651858.cd001800.pub4","url":null},{"study":"Does the muscle protein synthetic response to exercise and amino acid-based nutrition diminish with advancing age? A systematic review","doi":"10.1152/ajpendo.00213.2016","url":null}]},{"claim_id":"claim_4","claim":"In older-vs-younger comparisons, exercise plus amino-acid nutrition did not erase age-related anabolic-resistance uncertainty; only 2 of 10 combined-intervention arms provided sufficient evidence. DOI `10.1152/ajpendo.00213.2016`.","candidate_sources":[{"study":"Preoperative Exercise Training to Prevent Postoperative Pulmonary Complications in Adults Undergoing Major Surgery. A Systematic Review and Meta-analysis with Trial Sequential Analysis","doi":"10.1513/annalsats.202002-183oc","url":null},{"study":"Efficacy of Prehabilitation Including Exercise on Postoperative Outcomes Following Abdominal Cancer Surgery: A Systematic Review and Meta-Analysis","doi":"10.3389/fsurg.2021.628848","url":null},{"study":"Exercise-based cardiac rehabilitation for adults after heart valve surgery","doi":"10.1002/14651858.cd010876.pub3","url":null},{"study":"Exercise-based cardiac rehabilitation for coronary heart disease","doi":"10.1002/14651858.cd001800.pub4","url":null},{"study":"Does the muscle protein synthetic response to exercise and amino acid-based nutrition diminish with advancing age? A systematic review","doi":"10.1152/ajpendo.00213.2016","url":null}]}]}