{"publication_id":"10caf93e-a09c-432c-9878-611122b4890e","content_hash":"sha256:0b43fdc5f220d192e863733846b967a1342ff51c05504a8381e1855e7ae86b1e","nodes":[{"id":"10caf93e-a09c-432c-9878-611122b4890e","type":"publication","title":"Physical activity has a live counter-signal"},{"id":"claim_1","type":"claim","text":"The cited receipts show an apparent collision between a positive direct signal in colorectal cancer survivors (82,220 patients from 16 observational studies) (Physical activity was consistently inversely associated with colorectal cancer morbidity and mortality outcomes, with 13%-60% estimated reductions in risk) and an opposing endpoint in breast cancer patients post-diagnosis (Recreational physical activity was not associated with breast cancer recurrence (HR = 0.97, 95% CI: 0.91-1.05))."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"`fact_id=160470` (`A_core`) — Physical activity was consistently inversely associated with colorectal cancer morbidity and mortality outcomes, with 13%-60% estimated reductions in risk. doi=10.1002/ijc.34903"},{"id":"claim_4","type":"claim","text":"`fact_id=75409` (`A_core`) — High versus low adherence to established nutrition and physical activity cancer prevention guidelines was consistently and significantly associated with decreases of 10% to 61% in overall cancer incidence and mortality. doi=10.1158/1055-9965.epi-16-0121"},{"id":"claim_5","type":"claim","text":"`fact_id=75763` (`A_core`) — Interventions were associated with a lower risk of cardiovascular events (pooled relative risk, 0.80 [95% CI, 0.73-0.87]; doi=10.1001/jama.2020.17108"},{"id":"source_1","type":"source","study":"Post‐diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: A Global Cancer Update Programme (<scp>CUP</scp> Global) systematic literature review and meta‐analysis","year":2024,"doi":"10.1002/ijc.34903","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"Postdiagnosis recreational physical activity and breast cancer prognosis: Global Cancer Update Programme (<scp>CUP</scp> Global) systematic literature review and meta‐analysis","year":2022,"doi":"10.1002/ijc.34324","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Association between physical activity and mortality in colorectal cancer: A meta-analysis of prospective cohort studies","year":2013,"doi":"10.1002/ijc.28208","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_4","type":"source","study":"Adherence to Diet and Physical Activity Cancer Prevention Guidelines and Cancer Outcomes: A Systematic Review","year":2016,"doi":"10.1158/1055-9965.epi-16-0121","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_5","type":"source","study":"Behavioral Counseling to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors","year":2020,"doi":"10.1001/jama.2020.17108","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"10caf93e-a09c-432c-9878-611122b4890e","to":"claim_1","type":"contains_claim"},{"from":"10caf93e-a09c-432c-9878-611122b4890e","to":"claim_2","type":"contains_claim"},{"from":"10caf93e-a09c-432c-9878-611122b4890e","to":"claim_3","type":"contains_claim"},{"from":"10caf93e-a09c-432c-9878-611122b4890e","to":"claim_4","type":"contains_claim"},{"from":"10caf93e-a09c-432c-9878-611122b4890e","to":"claim_5","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}