{"publication_id":"06888b97-d174-4ea3-8963-a9e4112d22e8","traces":[{"claim_id":"claim_1","claim":"Receipt 1:** \"The NAD+ precursor nicotinamide riboside decreases exercise performance in rats\" (2016) — Chronic 21-day NR administration at 300 mg/kg/day in young Wistar rats showed a tendency toward worse swimming performance versus saline controls.","candidate_sources":[{"source_id":"source_1","study":"The NAD + precursor nicotinamide riboside decreases exercise performance in rats","doi":"10.1186/s12970-016-0143-x","url":"https://doi.org/10.1186/s12970-016-0143-x","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study.","doi":"10.1007/s00394-019-01919-4","url":"https://doi.org/10.1007/s00394-019-01919-4","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_2","claim":"Receipt 2:** \"Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study\" (2020) — Acute NR supplementation in older men (who exhibited lower erythrocyte NAD(P)H and higher urine F₂-isoprostanes at baseline) increased NAD(P)H levels, decreased oxidative stress, and improved VO₂-related performance, while no comparable benefit appeared in young subjects.","candidate_sources":[{"source_id":"source_1","study":"The NAD + precursor nicotinamide riboside decreases exercise performance in rats","doi":"10.1186/s12970-016-0143-x","url":"https://doi.org/10.1186/s12970-016-0143-x","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study.","doi":"10.1007/s00394-019-01919-4","url":"https://doi.org/10.1007/s00394-019-01919-4","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_3","claim":"Why this is surprising:** Receipt 1 made plausible the expectation that chronic NR would uniformly impair exercise output, yet Receipt 2 shows the same anchor can flip toward ergogenic benefit when baseline redox status is deficient, suggesting age-dependent reversal rather than a stable directional effect.","candidate_sources":[{"source_id":"source_1","study":"The NAD + precursor nicotinamide riboside decreases exercise performance in rats","doi":"10.1186/s12970-016-0143-x","url":"https://doi.org/10.1186/s12970-016-0143-x","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study.","doi":"10.1007/s00394-019-01919-4","url":"https://doi.org/10.1007/s00394-019-01919-4","support_kind":"candidate_source_row","population":"not extracted","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]}]}