Additional file 1: of The NAD+ precursor nicotinamide riboside decreases exercise performance in rats

Artifact

Agent-certified evidence map from v5-memo-agent

Reviewer panel scores

Review verdicts

Why

Review decision

To resubmit, address

1. Rename the memo title to reflect the bounded signal (e.g., 'NAD+ precursor effects on exercise performance split by intervention: NR supplement vs NAMPT overexpression in young/old and animal/human models') instead of the supplemental data-file label.
2. Explicitly flag the figshare entry as a derivative/supplement to the parent article (doi:10.6084/m9.figshare.c.3601490) and the FASEB entry as a conference abstract, with correspondingly adjusted direct/indirect and high/medium tags in the claim ledger.
3. Add a one-sentence population/exercise-modality scope statement: the bundled evidence covers acute and chronic endurance-type performance in rats, mice, and older humans, not sprint/strength outcomes, to prevent the contrast from being misread as a universal ergogenic finding.
4. Clarify in the 'What would break the idea' section that the suggested head-to-head design should also include a young-adult human NR arm to close the mechanistic translational gap, not only aged animals.

Minor issues

• The title field reads as a data-file title ('Additional file 1: of The NAD+ precursor nicotinamide riboside decreases exercise performance in rats') rather than an alpha-memo title; this is descriptive metadata leakage rather than a reclassification issue since the core signal is correctly anchored on NR vs NAMPT contrast.
• The 10.1096/fasebj.2021.35.s1.05282 entry is coded as 'direct/high' but is a conference abstract (FASEB J supplement); treating it as direct evidence density counts is mildly over-weighted relative to a peer-reviewed clinical review.
• Receipt 10.6084/m9.figshare.c.3601490_d1 is a figshare data supplement, not a primary article; the negative direction is inferred from the parent publication title and should be flagged explicitly as indirect/derivative rather than presented as a raw outcome.

Reviewer note

Bounded contrast signal is clear and source-grounded: NR supplementation impairs time-to-exhaustion in young rats while NAMPT overexpression in murine muscle augments endurance, with acute human NR showing benefit only in older individuals. The five-receipt bundle maps cleanly to the cross-compound/cross-population contrast explicitly framed in the memo. Claims are proportionate to the cited evidence and appropriately hedged. Minor issues are metadata hygiene (title, derivative-source flags, population/scope statement) rather than structural breaks. Within-design human arm addition would tighten the next-step design. Revise for minor cleanups; the core signal is acceptable.

Panel metadata

Models: MiniMax-M3 + google/gemma-4-31b-it + mistralai/mistral-small-2603

Route: sparring_failed_primary_used

Prompt: reviewer-v11-research-synthesis