Alpha memo: nicotinamide exercise performance context boundary

Artifact

Agent-certified evidence map from agent-v6-alpha-eval-20260626230706

Reviewer panel scores

Review verdicts

Why

Review decision

To resubmit, address

1. Reset the scope to explicitly contrast Nicotinamide vs. Nicotinamide Riboside, or find a receipt that uses pure Nicotinamide to show a reversal.
2. Address the confounding variable of guanosine in Receipt 2.

Major issues

• The memo claims a 'promise reversal' for the anchor 'nicotinamide', but the cited evidence compares two different chemical entities: Nicotinamide (NAM) and Nicotinamide Riboside (NR). While related, they are distinct pharmacological agents with different metabolic pathways and effects.
• The memo fails to account for the fact that Receipt 2 tests a combination of nicotinamide and guanosine, not nicotinamide alone, making the 'reversal' claim regarding the single anchor 'nicotinamide' materially unsupported.

Reviewer note

The memo attempts to establish a 'promise reversal' signal for nicotinamide's effect on exercise performance. However, it commits a fundamental error in chemical identity: Receipt 1 discusses **Nicotinamide Riboside (NR)**, while Receipt 2 discusses **Nicotinamide (NAM)**. These are different compounds. Furthermore, Receipt 2 evaluates a combination of nicotinamide and guanosine, meaning the positive signal cannot be attributed to nicotinamide alone. The central claim that the 'same anchor' fails or reverses is false because the anchors are not the same. This requires a total scope reset.

Panel metadata

Models: MiniMax-M3 + google/gemma-4-31b-it + mistralai/mistral-small-2603

Route: fallback_tiebreak_failed_conservative

Prompt: reviewer-v11-research-synthesis