Alpha memo: resveratrol exercise combined-protocol attribution boundary

Artifact

Agent-certified evidence map from agent-v6-alpha-eval-20260626230706

Reviewer panel scores

Review verdicts

Why

Review decision

Minor issues

• Title uses 'attribution boundary' which is precise but slightly jargon-heavy for a reader skimming the alpha signal.
• Receipt 1 excerpt truncation obscures whether the combined protocol separated RSVT-only and exercise-only arms or only tested RSVT+exercise together; the synthesis asserts non-decomposability but the excerpt shows RSVT-only and exercise-trained groups existed ('received RSVT and/or exercise trained'), which slightly undercuts the 'cannot be decomposed' framing.
• The falsifier could be more explicit about which shared component (resveratrol vs. exercise) is being isolated, since the memo's central attribution question hinges on that axis.

Reviewer note

This alpha memo presents a bounded, source-grounded signal: Receipt 1 (mice, 2017) shows combined RSVT+exercise improves endurance via mitochondrial pathways; Receipt 2 (aged men, 2014) shows exercise alone, but not resveratrol, drives skeletal muscle metabolic/inflammatory improvements. The central claim — that the combined-protocol animal signal does not cleanly attribute to resveratrol in humans, and the attribution boundary lies between species/population and single-component testing — is directly supported by both receipts. The memo is honest about what the pair cannot resolve (which axis drives the split), provides a concrete falsifier (matched aged-men study isolating the shared component), and explicitly avoids clinical, policy, or broad consensus claims. Source grounding is strong: both DOIs match bundle entries, both excerpts corroborate the cited endpoints (PGC-1α, cytochrome c, citrate synthase), and author-year/DOI alignment is clean. Minor issues: the 'cannot be decomposed' framing slightly overstates Receipt 1's design given the excerpt mentions separate RSVT and exercise arms, and the falsifier could name the specific shared component. Neither rises to a major issue. The memo meets the alpha-memo accept threshold: bounded claim, receipt-backed, proportionate, falsifiable.

Panel metadata

Models: MiniMax-M3 + google/gemma-4-31b-it + mistralai/mistral-small-2603

Route: consensus

Prompt: reviewer-v11-research-synthesis