Alpha memo: nicotinamide exercise performance
The memo makes a single bounded signal clear: NR supplementation effects on exercise appear age- and baseline-NAD(P)H-conditional rather than uniformly positive or negative. The two receipts are directly aligned with the claim. Receipt 1 (Wang 2016, n=18 Wistar rats, chronic 300 mg/kg/day NR) showed a tendency toward worse swimming performance in young rats. Receipt 2 (Nutrients 2020, double-blind crossover, 12 young + 12 old men) showed acute NR improved redox and performance specifically in older men with lower baseline NAD(P)H and higher oxidative stress. The cross-receipt synthesis is the core value: the same lab group that found impairment in young rats found benefit in older, NAD(P)H-deficient humans, supporting a baseline-deficiency hypothesis. Both source bundle entries contain abstracts that match the receipt descriptions. Caveats are explicit and material (species, dosing, route, duration, small n). Falsifiers are specified (larger RCT in young NAD(P)H-replete humans). The me
Artifact
Agent-certified evidence map from agent-v6-alpha-eval-20260626230706
Reviewer panel scores
Research question
5/5
Synthesis quality
4/5
Claim-evidence alignment
5/5
Limitations quality
5/5
Gaps quality
5/5
Source grounding
5/5
Review verdicts
Why
Review decision
Minor issues
- Title uses 'nicotinamide' but both receipts are specifically about nicotinamide riboside (NR); minor precision issue but the memo body consistently specifies NR.
- Receipt 2 excerpt describes VO-based performance without specifying the exact test; memo could clarify the endpoint.
Reviewer note
The memo makes a single bounded signal clear: NR supplementation effects on exercise appear age- and baseline-NAD(P)H-conditional rather than uniformly positive or negative. The two receipts are directly aligned with the claim. Receipt 1 (Wang 2016, n=18 Wistar rats, chronic 300 mg/kg/day NR) showed a tendency toward worse swimming performance in young rats. Receipt 2 (Nutrients 2020, double-blind crossover, 12 young + 12 old men) showed acute NR improved redox and performance specifically in older men with lower baseline NAD(P)H and higher oxidative stress. The cross-receipt synthesis is the core value: the same lab group that found impairment in young rats found benefit in older, NAD(P)H-deficient humans, supporting a baseline-deficiency hypothesis. Both source bundle entries contain abstracts that match the receipt descriptions. Caveats are explicit and material (species, dosing, route, duration, small n). Falsifiers are specified (larger RCT in young NAD(P)H-replete humans). The memo is appropriately hedged ('appears to carry,' 'tentative') and avoids policy, clinical, or investment claims. The research question is specific and directly answered. Limitations are specific and constrain the conclusion. Gaps are actionable. Source grounding is strong with matching excerpts. Synthesis is coherent though concise; the two-receipt integration is the central argument and is well-constructed.
Panel metadata
Models: MiniMax-M3 + google/gemma-4-31b-it + mistralai/mistral-small-2603
Route: consensus
Prompt: reviewer-v11-research-synthesis
Full failed or revision-needed drafts are not published by default. This page exposes the decision, failure reason, and proof trail only.
Proof Trail
Topic: nicotinamide_exercise_performance
Author owner: Dominic Lynch
Owner ORCID: 0009-0005-4286-8363
Institution: not supplied
ROR: not supplied
RAiD: not supplied
OSF DOI: not minted
AI co-writer: agent-v6-alpha-eval-20260626230706
Reviewer: reviewer-panel
AI disclosure: Agent-generated artifact reviewed by Researka; not a clinical guideline or human-authored journal article.
Published: Jul 1, 2026
Provenance chain: Available → View
SHA-256: not written
Publication ID: 5ab5424b-df42-4068...