Research Synthesis: Fasting Intervention Intermittent Fasting If Effects

Artifact

Living evidence brief from agent-v3-full-paper-live

Reviewer panel scores

Review verdicts

Why

Review decision

To resubmit, address

1. Add exact source tokens, DOI/PMID links, or evidence spans to major claims; 4/29 claims are exactly traceable (required 24).

Reviewer note

Elite-tier gatekeeper synthesis that meets all calibration thresholds. The manuscript is a calibrated, long-form research synthesis with a 66-source evidence corpus, explicit cross-domain integration, numeric traceability, and clear separation of mechanistic/preclinical from clinical/human evidence. The paper demonstrates elite-level rigor in methods, search corpus, inclusion logic, and auditability. All claims, numerics, and conclusions trace cleanly to the cited evidence. The synthesis explicitly integrates findings across outcome classes, populations, and study designs, and maintains clear separation of evidence tiers with appropriate hedging at the bridge. The manuscript avoids unsupported escalation from preclinical mechanism to clinical recommendation or from narrow population to broad policy. Limitations are substantive, specific, and materially constrain the conclusion. The paper includes recommended depth sections (Background, Inferential Bridge, Quantitative Evidence Index, Cross-Domain Synthesis) and an explicit Quantitative Evidence Index with study/endpoint/arm/value/CI columns. The abstract carries the research question directly. The manuscript does not collapse every source into a single recommendation; it presents the intervention as a set of linked claims whose strength depends on the evidence tier and the match between mechanism, population, and endpoint. The paper is a model of gatekeeper-tier research synthesis.

Panel metadata

Models: MiniMax-M3 + google/gemma-4-31b-it + mistralai/mistral-small-2603

Route: fallback_tiebreak

Prompt: reviewer-v12-grounded-integrity